LOGIC OF THE YEAST METABOLIC CYCLE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这是一个新项目。 细胞群落通常会表现出有组织的循环行为。虽然这种现象在复杂系统中的睡眠-觉醒周期和无数其他生物事件中很明显，但在简单的单细胞真核生物芽殖酵母中也观察到了周期性行为。我们已经开发了一种系统，使酵母在连续培养生长过程中表现出强大的，周期性的呼吸爆发。该项目旨在探索这些周期中的代谢波动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a new project. Communities of cells will often display organized cyclic behavior. Although this phenomenon is readily apparent in sleep-wake cycles and innumerable other biological events in complex systems, cyclic behavior has also been observed in the simple, unicellular eukaryote budding yeast. We have developed a system whereby yeast exhibit robust, cyclic bursts of respiration during continuous culture growth. This project is designed to probe the metabolic fluctuations during these cycles.