CHOLESTEROL REMOVING FROM DODAC VESICLES AND LIPOSOMES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们的工作是对一类非离子表面活性剂的物理化学研究，这类表面活性剂由不同长度的烷基链组成，并以蔗糖为端基。现在，我们强调在囊泡或脂质体中低于增溶临界点的浓度的存在的影响，以研究对几种囊泡性质的影响。 在这次访问中，与Susana Sanchez博士直接合作，我们试图澄清肉豆蔻醚衍生物的存在对从双层中去除胆固醇的影响。实验将在DODAC囊泡和POPC脂质体中进行

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our work consists in the physical chemical study of a family nonionic surfactants, consisting in different length of alkylic chains with a sucrose moiety as hydrophyllic head. Now we emphasize the on effect of the presence of concentrations below the solubilization critical point in vesicles or liposomes, in order to study the effects on several vesicular properties. In this visit, in direct collaboration with Dr, Susana Sanchez, we are trying to clarify the effect of the presence of the myristil derivative in the removing of cholesterol from the bilayer. The experiments are going to be performed in DODAC vesicles and POPC liposomes