DEVELOPMENT SMALL ANIMAL DIGITAL SUBTRACTION ANGIOGRAPHY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。具体目标1：我们将探索使用几种不同的K发射X射线源（W，Mo，Rh）来改善小动物数字减影血管造影术的对比噪声。K发射体的使用将通过以下方式改善对噪声的对比度：1）K发射体的通量产生在低能量下比Bremstrhalung更有效; 2）检测器磷光体的量子检测效率在较低能量下高得多（检测磷光体必须薄以限制来自光散射的分辨率降级）;以及3）软组织、钙化和碘/钆（潜在的血管造影剂）之间的光电吸收差异在较低能量下增加。 具体目标二：基于特定目标1中描述的模拟结果，我们将增强当前用于小动物数字减影血管造影的微型X射线系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: We will explore the use of several different K emission X-ray sources (W, Mo, Rh) to improve the contrast-to-noise for small animal digital subtraction angiography. Use of a K emitter will improve contrast to noise by: 1) flux production of the K emitters is much more efficient at low energies than Bremstrhalung; 2) the quantum detection efficiency of the detector phosphors is much higher at lower energies (detecting phosphors must be thin to limit resolution degradation from light scatter); and 3) photoelectric absorption differences between soft tissue, calcification and iodine/gadolinium (potential vascular contrast agents) increase at lower energy. Specific Aim 2: Based on simulation results described in Specific Aim 1, we will enhance our current micro-X-ray system for small animal digital subtraction angiography.