BETA CELL OXYGEN CONSUMPTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。线粒体在调节胰岛细胞的胰岛素分泌中起关键作用，并且响应于燃料促分泌素的氧消耗代表线粒体代谢的重要标志物。振荡代谢，包括氧消耗的振荡，被认为强调了从β细胞的脉动胰岛素输出。2型糖尿病患者的胰岛素分泌减少表明，胰岛素的振荡性分泌很重要。目前，通过磷酸果糖激酶（PFK）的振荡糖酵解已被认为是负责产生振荡胰岛素分泌的主要系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mitochondria play a key role in the regulation of insulin secretion from pancreatic islet cells, and oxygen consumption in response to fuel secretagogues represents an important marker of mitochondrial metabolism. Oscillatory metabolism, including oscillations in oxygen consumption, is believed to underline pulsatile insulin output from the beta cells. Oscillatory insulin secretion is important, as suggested by its loss in type 2 diabetic patients. Currently, oscillatory glycolysis via phosphofructokinas (PFK) has been considered the main system responsible for generation of oscillatory insulin secretion.