A Resource for magnetic resonance and optical imaging

描述（由申请人提供）： 区域资源的使命是为生物医学研究开发创新的磁共振（MR）和光学技术。这些技术是由生物医学领域的基础和临床研究合作者推动的，不仅解决了特定的临床问题，而且进一步加深了对体内生物系统的生物物理，生理，结构和功能特性的基本理解。与我们的合作者一起，我们已经开发了以下四个广泛的核心研究领域：第一个核心涉及开发新的MR技术，用于研究软骨，大脑和肿瘤的结构，生物化学和代谢方面，直接应用于关节炎，中风和阿尔茨海默病。核心I还开发了新的图像重建策略，以量化乳腺和其他组织中的高时间造影剂动态。在第二个核心中，我们提出了我们的研究发展的改进，定量灌注在高领域和儿科成像和方法，同时成像的血流和葡萄糖代谢。它还开发了功能磁共振成像与光学成像相关的策略。核心III子项目涉及超极化气体的MR和肺和鼻窦疾病研究的综合方法的开发。第四个也是最后一个核心集中在结合光学和磁共振成像技术，双光子光学成像的代谢成像和扩散断层扫描的神经生理学研究的图像重建策略的方法的发展，和乳腺癌。这些核心开发的技术将推动20个合作项目，研究各种正常和病理生理组织，并根据需要支持服务项目。该资源提供的服务包括使用1.5T、2T、3T研究磁体系统、4.7T动物磁体、线圈设施、光学成像设施、极化气体成像装置、磁内运动设备和该资源开发的计算机软件。该资源还维护一个广泛的培训和传播计划，包括研讨会，MR课程，讲习班，培训讲座，MR和光学方法的实践培训，时事通讯，在国家和国际会议上的演讲，以及一个资源网站，提供访问所有出版物和软件包的资源。宾夕法尼亚大学放射学系赞助的研究资源仍然致力于知识交流和基础和临床医学的跨学科追求。

DESCRIPTION (provided by applicant): The mission of the regional resource is to develop innovative magnetic resonance (MR) and optical technologies for biomedical research. These technologies are driven both by basic and clinical research collaborators in the biomedical field to not only address specific clinical problems but also to further fundamental understanding of biophysical, physiological, structural, and functional properties of biological systems in vivo. In conjunction with our collaborators, we have developed the following four broad areas of core research: The first core deals with the development of novel MR techniques for studying the structural, biochemical and metabolic aspects of cartilage, brain, and tumors, with direct application to arthritis, stroke, and Alzheimer's disease. Core I also develops novel image reconstruction strategies to quantify high temporal contrast agent dynamics in breast and other tissues. In the second core, we present our research on the development of improved, quantitative perfusion at high fields and in pediatric imaging and methods for concurrent imaging of blood flow and glucose metabolism. It also develops strategies for correlation of fMRI with optical imaging. Core III subprojects deal with MR of hyperpolarized gases and development of a comprehensive approach for the study of pulmonary and sinuses diseases. The fourth and final core focuses on combining optical and MR imaging techniques, development of methods of two photon optical imaging for metabolic imaging and image reconstruction strategies in diffusion tomography for the study of neurophysiology, and breast cancer. Technology developed by these cores will drive twenty collaborative projects in the study of various normal and pathophysiological tissues and support service projects as required. Service provided by the resource includes access to the 1.5T, 2T, 3T research magnet systems, 4.7T animal magnet, coil facility, optical imaging facility, polarized gas imaging set-up, in-magnet exercise devices, and computer software developed by the resource. The resource also maintains an extensive training and dissemination program consisting of seminars, MR courses, workshops, training lectures, practical training in MR and optical methods, and newsletters, presentations at national and international conferences, and a resource web site that provides access to all publications and software packages developed by the resource. The research resource with the auspices of the Radiology department at the University of Pennsylvania remains committed to intellectual interchange and the interdisciplinary pursuit of basic and clinical medicine.