National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative Resource

国家青少年酒精与神经发育联盟 (NCANDA)：行政资源

• 批准号: 10888826
• 负责人: SANDRA A BROWN
• 金额: $ 3.95万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-04 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10888826
• 关键词: Acceleration; Administrative Supplement; Adolescence; Adolescent; Adult; Age; Alcohols; Archives; Behavior; Behavioral; Biological; Brain scan; Cellular Phone; Clinical; Cognitive; Collection; Communities; Complement; Computers; Data; Data Analyses; Ecological momentary assessment; Ensure; Functional Magnetic Resonance Imaging; Funding; Goals; Growth; Health Sciences; International; Magnetic Resonance Imaging; Measures; Monitor; Moods; Oregon; Participant; Persons; Physical activity; Positioning Attribute; Research Project Grants; Resolution; Resources; Rest; Site; Sleep; System; Time; Universities; data archive; data de-identification; digital technology; fitbit; longitudinal design; meetings; mobile application; multimodal neuroimaging; neural; neurodevelopment; neuroimaging; success

ABSTRACT The purpose of this Administrative Supplement is to request additional funds for meeting the aims of the Administrative Resource (AR U24 AA021695) of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A), specifically by providing clearly defined and well-organized non-imaging data to share with the scientific community through the National Data Archive (NDA). The goals and objectives of the NCANDA AR are to ensure the success of the consortium. The NCANDA-A consortium includes an Administrative Resource (UCSD), a Data Analysis Resource (SRI), and five cross-national Research Project Sites located at Duke University (Duke), Oregon Health Science University (OHSU), University of Pittsburgh (Pitt), SRI International (SRI), and UC San Diego (UCSD). Monitoring has involved annual multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging, sleep data, and physical activity tracking. Our accelerated longitudinal design uniquely positions NCANDA-A (ages 18-34) to quantify transient and enduring alcohol-related disturbances in adolescent and early adult neural system growth trajectories and functional concomitants. This supplement will provide the resources needed to archive existing NCANDA data collected using digital technologies collected at a higher time resolution than most of the NCANDA data. Specifically, NCANDA developed a mobile phone application called mNCANDA to assess alcohol, other substance, mood, and behavior data several times per day in weeks preceding annual brain scans, and weekly throughout the year. NCANDA now has 5 years of data ecological momentary assessment (EMA) data collected via mNCANDA as well as 6 months of Fitbit data collected as well as ongoing collection underway with both. This 1-year supplement will provide the expertise and person power needed to (1) organize these data forms to provide summary variables that time-lock with other NCANDA data, and (2) curate the raw mNCANDA data that can be shared and used meaningfully by the scientific community. This will be done for all available data from all 831 NCANDA participants at NCANDA’s 5 sites.

摘要 本行政补充文件的目的是要求增加资金，以实现 国家酒精和神经发育联盟的行政资源（AR U24 AA021695）， 青少年-成年（NCANDA-A），特别是通过提供明确定义和组织良好的非成像 通过国家数据档案馆（NDA）与科学界分享数据。各项目的和目标 NCANDA AR的目的是确保联合体的成功。NCANDA-A财团包括一个 行政资源（UCSD），数据分析资源（SRI）和五个跨国研究项目 位于杜克大学（杜克）、俄勒冈州健康科学大学（OHSU）、匹兹堡大学的研究中心 （皮特），SRI国际（SRI）和加州大学圣地亚哥分校（UCSD）。监测工作涉及年度多式联运 神经成像（MRI、DTI、静息状态fMRI、任务fMRI）、认知、临床、行为和生物学数据， 亲自或通过计算机和我们的移动的应用程序远程收集。这些措施现在将得到补充 新的先进神经成像、睡眠数据和身体活动跟踪。我们的加速纵向设计 独特定位NCANDA-A（18 - 34岁），以量化短暂和持久的酒精相关性障碍， 青少年和早期成人神经系统的生长轨迹和功能伴随。该补充将 提供所需的资源，以存档使用数字技术收集的现有NCANDA数据， 比大多数NCANDA数据的时间分辨率更高。具体来说，NCANDA开发了一款移动的手机， 应用程序称为mNCANDA，以评估酒精，其他物质，情绪和行为数据多次， 在年度脑部扫描之前的几周内，以及全年每周。NCANDA现在有5年的数据 通过mNCANDA收集的生态瞬时评估（EMA）数据以及6个月的Fitbit数据 收集以及正在进行的收集与两者。这一年的补充将提供专业知识， 和人力所需的（1）组织这些数据形式，以提供汇总变量， 其他NCANDA数据，以及（2）管理可以共享和有意义地使用的原始mNCANDA数据， 科学界。这将对NCANDA第5次会议上所有831名NCANDA参与者的所有可用数据进行分析。 网站.

项目成果

Neuroinformatics Software Applications Supporting Electronic Data Capture, Management, and Sharing for the Neuroimaging Community.

• DOI: 10.1007/s11065-015-9293-x
• 发表时间: 2015-09
• 期刊: Neuropsychology review
• 影响因子: 5.8
• 作者: Nichols BN;Pohl KM
• 通讯作者: Pohl KM