National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative Resource

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ABSTRACT The purpose of this Administrative Supplement is to request additional funds for meeting the aims of the Administrative Resource (AR U24 AA021695) of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A), specifically by providing clearly defined and well-organized non-imaging data to share with the scientific community through the National Data Archive (NDA). The goals and objectives of the NCANDA AR are to ensure the success of the consortium. The NCANDA-A consortium includes an Administrative Resource (UCSD), a Data Analysis Resource (SRI), and five cross-national Research Project Sites located at Duke University (Duke), Oregon Health Science University (OHSU), University of Pittsburgh (Pitt), SRI International (SRI), and UC San Diego (UCSD). Monitoring has involved annual multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging, sleep data, and physical activity tracking. Our accelerated longitudinal design uniquely positions NCANDA-A (ages 18-34) to quantify transient and enduring alcohol-related disturbances in adolescent and early adult neural system growth trajectories and functional concomitants. This supplement will provide the resources needed to archive existing NCANDA data collected using digital technologies collected at a higher time resolution than most of the NCANDA data. Specifically, NCANDA developed a mobile phone application called mNCANDA to assess alcohol, other substance, mood, and behavior data several times per day in weeks preceding annual brain scans, and weekly throughout the year. NCANDA now has 5 years of data ecological momentary assessment (EMA) data collected via mNCANDA as well as 6 months of Fitbit data collected as well as ongoing collection underway with both. This 1-year supplement will provide the expertise and person power needed to (1) organize these data forms to provide summary variables that time-lock with other NCANDA data, and (2) curate the raw mNCANDA data that can be shared and used meaningfully by the scientific community. This will be done for all available data from all 831 NCANDA participants at NCANDA’s 5 sites.