CURCUMIN BINDING MODES IN HIV PROTEASE AND INTEGRASE ACTIVE SITES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。人类免疫缺陷病毒1型（HIV-1）是获得性免疫缺陷综合征（AIDS）的病原。HIV-1复制周期的独特性质为化疗干预提供了许多潜在的靶点。姜黄；姜黄（姜黄科）是一种广泛种植于亚洲热带地区的药用植物。姜黄根茎提取物通常称为姜黄素，主要由约75-95%的姜黄素和少量的去甲氧基姜黄素和双去甲氧基姜黄素组成。除了其强大的抗氧化活性外，其在生物系统中的各种相关活性已被广泛研究。姜黄素已被证明具有抗炎、胃肠道活性和抑制多种蛋白激酶的活性，包括蛋白激酶C和磷酸化激酶。据报道，姜黄素还能抑制癌变和肿瘤生长。最近，姜黄素被报道可以抑制HIV的复制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS). The unique nature of the replication cycle of HIV-1 provides many potential targets for chemotherapeutic intervention. Curcuma longa Linn. or turmeric (Zingiberaceae) is a medicinal plant widely cultivated in tropical regions of Asia. Turmeric extract from the rhizomes commonly called curcumin is mainly composed of curcumin, about 75-95% and a small amount of demethoxy curcumin and bisdemethoxycurcumin. In addition to its potent antioxidant activity, various related activities in biological systems have been extensively investigated. Curcumin has been shown to exhibit anti-inflammatory, gastrointestinal activity, and inhibitory activity against a variety of protein kinases including protein kinase C and phosphoryl kinase. Curcumin is also reported to inhibit carcinogenesis and cancer growth. More recently, curcumin has been reported to inhibit HIV replication.