Effects of Alcohol and Prior Gambling Outcomes on Gambling Behavior

描述（由申请人提供）：本研究计划的广泛，长期目标是通过提高我们对酒精使用和会话内赌博行为之间关系的理解，减少同时发生的酒精使用和赌博行为紊乱的患病率，并最大限度地减少与之相关的负面后果。尽管这些行为的共同发生，现存的经验证据证明酒精对会话内赌博行为的影响是有限的。持续性和相关的赌博行为可能导致不断增加的经济损失，这反过来又可能导致未来赌博活动的开始，并对个人造成更大的伤害。因此，这项研究的主要目的是阐明酒精对赌博持续性和赌博行为的影响。这一目标将通过评估酒精的主要影响以及酒精影响的潜在调节剂和介质来实现。在解决研究的主要目的之前，有必要开发一个外部有效的视频扑克软件程序作为标准任务。该计划将通过平板电脑与触摸屏技术在模拟酒吧实验室管理。为了实现主要研究目的，将招募200名年龄在21-30岁之间的成年人（100名男性和100名女性）进行2阶段安慰剂对照酒精给药研究，目标是酒精条件下呼气酒精浓度（BrAC）为0.08 g%，活性安慰剂条件下为0.01 g%。在第一次会议期间，参与者将完成冲动和饮料管理的行为测量，并将有机会在视频扑克任务上赌博。参与者将被随机分配到三个初始赌博结果操纵之一（即，赢、盈亏平衡或输），其将包括博弈任务的前5次试验。在操纵之后，所有参与者将开始渐进损失计划。饮酒和赌博史、行为抑制/冲动和赌博相关认知的测量将在第二次会议期间通过自我报告和访谈进行。饮料条件，最初的赌博结果，冲动性和赌博相关的认知将分别作为赌博持续性和赌博行为的预测因子。此外，最初的赌博结果，冲动性和赌博相关的认知将作为潜在的调解人和/或调解人的酒精对赌博行为的影响。

DESCRIPTION (provided by applicant): The broad, long-term objective of this program of research is to reduce the prevalence of, and minimize the negative consequences associated with, co-occurring alcohol use and disordered gambling behavior by improving our understanding of the relation between alcohol use and within-session gambling behavior. Despite the common co-occurrence of these behaviors, the extant empirical evidence documenting alcohol's influence on within-session gambling behavior is limited. Persistence and related betting behaviors can contribute to mounting financial losses which, in turn, can lead to initiation of future gambling sessions and greater harm to the individual. Thus, the primary aim of the proposed study is to elucidate the effects of alcohol on gambling persistence and betting behavior. This aim will be met through the evaluation of alcohol main effects as well as potential moderators and mediators of alcohol effects. Prior to addressing the primary aim of the study, it is necessary to develop an externally valid video poker software program to serve as the criterion task. The program will be administered via tablet PCs with touch screen technology in a simulated bar lab. To accomplish the primary study aims two-hundred adults (100 men and 100 women) between the ages of 21-30 will be recruited for a 2-session placebo-controlled alcohol administration study targeting a breath alcohol concentration (BrAC) of 0.08 g% in the alcohol condition and 0.01 g% in the active placebo condition. During the first session, participants will complete a behavioral measure of impulsivity and beverage administration, and will have the opportunity to gamble on the video poker task. Participants will be randomly assigned to one of three initial gambling outcome manipulations (i.e., win, breakeven, or lose) which will comprise the first 5 trials of the gambling task. Following the manipulation all participants will begin a progressive loss schedule. Measures of drinking and gambling history, behavioral inhibition/impulsivity, and gambling related cognitions will be administered via self-report and interview during the second session. Beverage condition, initial gambling outcomes, impulsivity, and gambling related cognitions will each serve as predictors of gambling persistence and betting behavior. Further, initial gambling outcomes, impulsivity, and gambling related cognitions will serve as potential moderators and/or mediators of alcohol effects on gambling behavior.