Admixture Mapping for Insulin Complex Outcomes

描述（由申请方提供）：在流行病学研究中已经确定了糖尿病发病率的种族和民族差异。虽然最近的研究已经将遗传标记和环境因素与人群中的糖尿病相关表型相关联，但这些因素实际上在多大程度上导致种族/民族差异仍不清楚。本研究的主要目的是调查遗传和环境参数对种族/民族差异的糖尿病相关性状的影响，通过模拟个体估计的遗传混合物和环境措施的能量摄入，能量消耗和社会经济地位（SES）的措施，空腹胰岛素，胰岛素敏感性和胰岛素分泌的初始阶段暴露于葡萄糖后。 将对120名7-13岁的非洲裔美国人（AA）、120名欧洲裔美国人（EA）和120名西班牙裔美国人（HA）男孩和女孩的样本进行测试，以获得胰岛素作用和反应、身体组成、能量摄入和能量消耗对问卷和SES的结果。这项调查的具体目的是：（a）测试欧洲遗传混合物在调整身体组成参数后对空腹胰岛素（FI）、胰岛素敏感性（Si）和胰岛素对葡萄糖的反应（AIRg）的糖尿病相关测量的作用。（2）研究环境参数能量摄入、能量消耗和社会经济地位作为混合物和糖尿病相关的空腹胰岛素（FI）、胰岛素敏感性（Si）和胰岛素对葡萄糖的反应（AIRg）测量的函数而不同，（3）对AA、HA和EA青春期前儿童样本进行校正身体成分和环境参数后的FG、Si和AIRg测量值与祖先信息标记（AIMs）之间的表型-基因型关联性检验。拟议的调查将提供有意义的和重要的洞察力的生物，非生物和两个组件的相互作用的种族/民族差异的糖尿病相关性状的理解。此外，这项调查的结果将作为制定有效预防策略的工具，以减少种族/民族人群中糖尿病及其相关特征的患病率。

DESCRIPTION (provided by applicant): Racial and ethnic differences in the incidence of diabetes have been identified in epidemiological studies. Although recent investigations have associated genetic markers and environmental factors contributing to the diabetes-related phenotypes within populations, the extent to which these factors in fact account for racial/ethnic differences is still unclear. The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in diabetes-related traits by modeling individual estimates of genetic admixture and environmental measures of energy intake, energy expenditure and socioeconomic status (SES) on measures of fasting insulin, sensitivity to insulin and initial phase of insulin secretion after exposure to glucose. A sample of 120 African-American (AA), 120 European-American (EA) and 120 Hispanic-American (HA) boys and girls of 7-13 years of age will be tested to obtain outcomes of insulin action and response, body composition, energy intake and energy expenditure to questionnaire and SES. The specific aims of this investigation are: (a) To test the role of European genetic admixture on diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg) after adjusted for body composition parameters (2) To investigate how the relationship between the environmental parameters energy intake, energy expenditure and socioeconomic status differ as a function of admixture and diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg), and (3) To test phenotype-genotype associations between ancestry-informative markers (AIMs) and measures of FG, Si and AIRg after adjusted for body composition and environmental parameters in a sample of AA, HA and EA prepubertal children. The proposed investigation will provide meaningful and important insight into the understanding of biological, non-biological and the interaction of both components in racial/ethnic differences in diabetes-related traits. Furthermore, the results of this investigation will serve as a tool for the development of effective preventive strategies to reduce the prevalence of diabetes and its related traits in racial/ethnic populations.