KINESIN-INHIBITOR COMPLEX STRUCTURE DETERMINATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。驱动蛋白是一组ATP依赖性马达蛋白的成员，对于多种基于微管的细胞运输事件是必需的。我们提出的研究的目标是获得结构信息的运动域的驱动蛋白超家族成员时，绑定到专有的抑制剂。我们获得的信息将被用来确定抑制剂的结合位点，并获得更好地了解这种驱动蛋白的构象状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Kinesins are members of a group of ATP-dependent motor proteins essential for a variety of microtubule based cellular transport events. The goal of our proposed research is to obtain structural information for a motor domain of a kinesin superfamily member when bound to a proprietary inhibitor. The information we acquire will be used to identify the binding site for the inhibitor and to gain a better understanding of the conformational states of this kinesin.