HIGH FIELD MAGNETIC RESONANCE RESEARCH AND TECHNOLOGY

超出提供的空间。 该资源的总体目标是开发强磁场的技术和技术 磁共振成像和光谱学，以支持重大生物医学问题的研究。我们正处于黄金时期 通过收购世界上最高的两台外业仪器；750 MHz/9 cm和 11.7T/40 cm成像光谱仪。向更高场强的推动是由信号的增加所驱动的 强度和光谱分辨率在较高的场中可用。这些改进将用于开发 通过地方、国家和国际合作项目实现MR在生物医学上的应用。这些 目标得到了佛罗里达大学(UF)和佛罗里达州立大学之间强大的协同作用的支持 作为国家强磁场实验室(NHMFL)的合作伙伴，得到了 密歇根大学麦克奈特脑研究所。 如果不开发相关的技术和技术，那么更强的磁铁就没有什么意义了- 事实上，如果不这样做，潜在的收益就会消失。这些发展构成了这项提议的基础，并且 将通过三个研究核心和一个行政核心进行，以支持19个协作 项目(15个已资助，4个待定)和7个服务项目(6个已资助)。三个核心聚焦于敏感度 改进(1)高场小动物成像和光谱分析(新型大体积相控阵 线圈)、(2)显微成像和空间局域显微光谱学(微线圈、微相控阵、强 梯度线圈和高场成像技术)和(3)高灵敏度和高通量溶液状态 核磁共振光谱学(微线圈、多线圈阵列、高温超导探针)。协作 项目范围从癌症、中风、脑积水、脑缺血、脑和脊髓创伤、艾滋病毒、 糖尿病，癫痫，阿尔茨海默病，DCA毒性，骨剂量学，通过蛋白质折叠，结构-功能 研究和药物设计，以及对组织中磁共振信号来源的基础研究。资源将 提供培训并传播从这些研究中获得的知识。

EXCEED THE SPACE PROVIDED. The overall objective of this Resource is to develop technology and techniques for high magnetic field MR imaging and spectroscopy to support the study of significant biomedical problems. We are in a prime position to do this through the acquisition of two of the world's highest field instruments; a 750MHz/9cm and a 11.7T/40cm imaging spectrometer. The push towards higher field strengths is driven by increases in signal strength and spectral resolution available at higher fields. These improvements will be used to develop biomedical applications of MR through collaborative projects locally, nationally and internationally. These objectives are supported by a strong synergy between the Universityof Florida (UF) and Florida State University (FSU) as partners in the National High Magnetic Field Laboratory (NHMFL), with support from the McKnight Brain Institute at UF. There is little point in stronger magnets if the associated technology andtechniques are not developed - indeed, the potential gains would otherwise be lost. These developments form the basis of this proposal, and will be carried out through three research cores plus an administrative core, in support of 19 collaborative projects (15 funded, 4 pending) and 7 service projects (6 funded). The three cores focus on sensitivity improvements for (1) high field small animal imaging and spectroscopy (novel large volume and phased array coils), (2) microimaging and spatially localized microspectroscopy (microcoils, microphased arrays, strong gradient coils, and high field imaging techniques) and (3) high sensitivity and high throughput solution-state NMR spectroscopy (microcoils, multicoil arrays, high temperature superconducting probes). The collaborative projects range from studies of cancer, stroke, hydrocephalus, ischemia, and brain and spinal cord trauma, HIV, diabetes, epilepsy, Alzheimers, DCA toxicity, bone dosimetry, through protein folding,structure-function studies and drug design, as well as basic studies on the origins of MR signals in tissues. The Resource will provide training and disseminate knowledge resulting from these studies.