Gulf South STI/Topical Microbicide Cooperative Res Cent

描述（由申请人提供）：南海湾性传播感染/局部杀微生物剂合作研究中心（STI TM CRC）的主题是“性传播感染高危妇女：重点研究最需要的地方”。该中心将有四个项目和四个核心。这四个项目将侧重于以下方面：宫颈T细胞对衣原体感染的应答，2。生殖支原体在女性不孕症中的作用。3. 生殖道组织中toll样受体（TLRs）的生物学特性以及TLR激动剂作为预防高危女性性传播感染的新型局部杀微生物剂的潜力4. 治疗失败和再次感染在甲硝唑治疗后复发性阴道毛滴虫感染中的作用。这个CRC将有行政、实验室、临床和生物统计学核心。此外，这个应用程序还有两个特殊的方面。一个是职业中期指导计划，旨在为职业中期研究者提供高级指导，努力达到他们所选择的科学领域的顶峰。另一个是一个重要的努力，以发展现代分子方法的阴道生态系统的研究，将包括在实验室核心。我们的Gulf South STI TM CRC申请建议在人口遭受性传播感染长期后遗症不成比例的地区中心建立一个新的CRC。为该中心提供资金将在未来多年对这一高风险地区的性传播感染产生重大的社会和公共卫生影响。

DESCRIPTION (provided by applicant): The theme of the Gulf South Sexually Transmitted Infections/Topical Microbicide Cooperative Research Center (STI TM CRC) is "Women at high risk for STI's: Focusing research where it is needed the most." There will be four projects and four cores within this CRC. The four projects will focus on the following: 1. Cervical T cell responses to chlamydial infection, 2. The role of Mycoplasma genitalium in infertility in women. 3. The biology of toll-like receptors (TLRs) in genital tract tissues and the potential of TLR agonists as new topical microbicide candidates for use in preventing STI's in high risk women. 4. The role of treatment failure and re-infection in recurrent Trichomonas vaginalis infections following metronidazole treatment. This CRC will have administrative, laboratory, clinical, and biostatistics cores. In addition there are two special aspects of this application. One is a mid-career mentoring program designed to provide senior level guidance to mid-career investigators endeavoring to reach the top of their chosen scientific fields. The other is an important effort to develop modern molecular methods for the study of the vaginal ecosystem that will be included within the Laboratory Core. Our Gulf South STI TM CRC application proposes to create a new CRC in the heart of an area whose population suffers disproportionately from the long term sequelae of STIs. Funding this center will have significant social and public health impact on STIs in this high risk region for many years into the future.