A PROBABILISTIC REFERENCE SYSTEM FOR THE HUMAN BRAIN: PET

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：本项目的具体目标是为人脑开发一个数字概率参考系统。将邀请来自母方案的受试者入组本方案。本研究的目的是获得规范的PET FDG数据，这将有利于在疾病状态下进行FDG PET的其他研究。 研究方案和方法：将邀请母方案中的50例受试者入组本PET成像方案。受试者将接受FDG PET。扫描预计需要1.5-2小时。 临床相关性：该提案是对NIH资助的P20项目的补充，该项目已进入第九年。前五年采集了18-40岁受试者的解剖数据。目前的资助周期正在收集40岁以上受试者的解剖和功能数据。父协议正在获取功能激活数据。目前提出的方案寻求获得静息状态的葡萄糖代谢，以确定神经元密度。本研究中获得的初步数据将用于向NIH衰老研究所提交的资助申请。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: This project has the specific goal of developing a digital probabilistic reference system for the human brain. Subjects from the parent protocol will be invited to enroll in this protocol. The purpose of the proposed study is to obtain normative PET FDG data, which will benefit other studies doing FDG PET in disease states. RESEARCH PLAN AND METHODS: Fifty subjects from the parent protocol will be invited to enroll in this PET imaging protocol. Subjects will have a FDG PET. Scans are expected to take 1.5-2 hours. CLINICAL RELEVANCE: This proposal is a supplement to a NIH funded P20 in its ninth year of funding. The first five years acquired anatomical data on subjects ages 18-40. The current funding cycle is acquiring anatomical and functional data on subjects over 40. The parent protocol is acquiring functional activation data. The current proposed protocol seeks to obtain resting state glucose metabolism to determine neuronal density. The preliminary data that will be acquired in this study will be used in a grant submission to the NIH aging institute.