A STUDY ON THE EFFECT OF TX ON QUALITY OF LIFE FOR MEN WITH PROSTATE CA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：这个项目将调查决策者（患者，配偶和医生）的“三位一体”，以深入了解如何做出前列腺癌治疗决策。通过在治疗前对三联征进行调查，我们有机会在做出这些决定时确定影响。 研究：我们将从调查治疗前的三位决策者开始。这种方法将使我们有机会在决策时确定影响因素。在治疗或观察等待之后，我们将对患者和配偶进行调查，以确定在做出决定时不相关的问题。我们将确定这些因素是否影响生活质量和治疗满意度。我们还将评估患者的偏好、医生的建议和其他因素在多大程度上导致了男性在前列腺癌方面做出的巨大种族和社会经济差异。 方法：基线调查的目的是在治疗前即刻收集社会人口学信息、生活质量和合并症。我们将确定患者及其家属收到的信息的来源和类型。我们将描述决策者之间的相互作用，并确定在决定治疗偏好的影响因素。通过测量所有三个决策者（患者，配偶/家庭成员和医生）的反应，我们可以调查这些人之间的相互作用以及他们的个人偏好如何影响治疗决策。随访调查的目的是了解患者和家庭成员在治疗后偏好如何变化，并了解这些变化如何与患者特定结局相关，包括癌症特定和全球健康相关生活质量。最后的调查工具将利用各种经过验证的调查工具，并将通过重点小组访谈和试点测试的过程提出问题。 临床相关性：本研究将评估限制患者做出知情选择的问题。本研究还将从其他因素中理清前列腺癌治疗选择对生活质量和护理满意度的影响。如果这些短期目标得以实现，长期目标是帮助前列腺癌患者及其配偶或伴侣做出明智的决定，反映他们的价值观和对治疗的期望。这项研究的信息将被用作未来干预研究的基础，旨在改善决策，对治疗过程的满意度和局限性前列腺癌男性的生活质量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: This project will survey the "triad" of decision-makers (patient, spouse, and physician) to gain insight into how prostate cancer treatment decisions are made. By surveying the triad before treatment, we have the opportunity to identify influences at the time these decisions are made. RESEARCH PLAN: We will start by surveying the triad of decision-makers before treatment. This approach will give us the opportunity to identify influences at the time of the decision. Following treatment, or watchful waiting, we will survey patients and spouse to identify issues that, in retrospect, were irrelevant at the time of the decision was being made. We will determine whether these factors influence quality of life and treatment satisfaction. We will also evaluate the degree to which patient preferences, physicians' recommendations and other factors account for the considerable racial and socioeconomic disparity in the choices men make regarding their prostate cancer. METHODS: The objective of the baseline survey is to collect sociodemographic information, quality of life and co-morbidity, immediately prior to treatment. We will identify the sources and type of information patients and their family members receive. We will characterize interactions among decision-makers and identify influential factors in determining treatment preference. By measuring responses from all three decision-makers (patient, spouse/family member and physician), we can investigate the interactions between these individuals and how their individual preferences influence the treatment decision. The goal of the follow-up survey is to understand how preferences change, following treatment for patients and family members, and understand how these changes are associated with patient-specific outcomes including cancer specific and global health-related quality of life. The final instruments will utilize a variety of validated survey instruments and will develop questions, through a process of focus group interviews and pilot testing. CLINICAL RELEVANCE: This study will assess issues that limit persons from making informed choices. This study will also disentangle the influence of prostate cancer treatment choices from other factors on QOL and satisfaction with care. If these short term objectives are achieved, the long term goals are to help prostate cancer patients and their spouse or partner make well-informed decisions reflecting their values and expectations for treatment. The information from this study will be used as the basis for future intervention studies designed to improve decision-making, satisfaction with the treatment process and quality of life for men with localized prostate cancer.