ALZHEIMER'S DISEASE RESEARCH CENTER AD PATIENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。肯塔基大学阿尔茨海默病研究中心(英国ADRC)临床核心中心的总体目标是支持ADRC的研究使命，为阿尔茨海默病(AD)和非AD痴呆障碍患者提供出色的临床诊断和护理。它将：(1)维持500名最初正常的老年受试者的正常对照(脑诊所)，这些受试者将被纵向追踪进行尸检。将重点放在正常衰老和过渡到轻度认知障碍(MCI)和早期AD；(2)维持一个由200名可能患有AD和其他非AD痴呆的受试者组成的研究诊所，纵向追踪尸检；以及(3)建立一个由100名最初正常的阿巴拉契亚农村老年受试者组成的小组，在伯里亚农村阿巴拉契亚卫星诊所进行纵向尸检，以与设在城市的脑诊所进行比较。控制组参与者每年都会接受神经心理测试，以检测记忆和其他认知功能的细微变化，以检测过渡到MCI和痴呆症。英国许多现有的和计划中的研究项目依赖于正常受试者和MCI或早期AD患者的尸检样本。核心召开重要的共识诊断会议，并与神经病理学、生物统计学和数据管理核心密切相关。临床核心中心将在转介记忆障碍评估诊所为每年约300名患者提供痴呆症专家诊断服务，这一群体将作为研究诊所以及临床试验和其他研究研究的招募池。该核心中心将在列克星敦为非裔美国人扩大和维持一家诊所，即肯塔基州诊所北少数族裔强调诊所，为研究不足的人群提供纵向护理并扩大研究机会。该核心参与了NIA负荷遗传倡议、NACC资助的研究和ADCS试验。所有适当的数据都被及时收集并提交给国家反腐败委员会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the Clinical Core of The University of Kentucky Alzheimer's Disease Research Center (UK ADRC) is to support the research mission of the ADRC and provide excellent clinical diagnoses and care for patients with Alzheimer's disease (AD) and non-AD dementing disorders. It will: (1) maintain a normal control (BRAiNS clinic) of 500 initially normal aged subjects, who will be followed longitudinally to autopsy. Emphasis will be on normal aging and transition to Mild Cognitive Impairment (MCI) and early AD; (2) maintain a Research Clinic of 200 subjects with probable AD and other non-AD dementias who will be followed longitudinally to autopsy; and (3) establish a group of 100 initially normal rural Appalachian aged subjects followed longitudinally to autopsy in the Berea Rural Appalachian Satellite Clinic for comparison to the urban based BRAiNS Clinic. The control participants are evaluated annually using neuropsychological tests to detect subtle changes in memory and other cognitive function designed to detect transition to MCI and dementia. Many existing and planned research projects at UK are dependent on autopsy specimens from normal subjects and those with MCI or early AD. The core holds important consensus diagnostic conferences and relates closely to the Neuropathology and Biostatistics and Data Management Cores. The Clinical Core will provide expert dementia diagnostic services in a referral Memory Disorders Evaluation Clinic for approximately 300 patients per year, a group which serves as a recruiting pool for the Research Clinic and for clinical trials and other research studies. The core will expand and maintain a clinic for African Americans in Lexington, the Kentucky Clinic North Minority Emphasis Clinic, providing longitudinal care and broadening research opportunities to an understudied population. This core participates in the NIA LOAD genetic initiative, NACC funded studies and ADCS trials. All appropriate data are collected and submitted to NACC in a timely manner.