SKELETAL EFFECTS OF BUFFER IN HIV INFECTION (PART B) ALSO SEE SPID 0698

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。患有HIV感染和最近有过量体酸证据的志愿者患者将每天3次随餐吞咽惰性材料（安慰剂），持续2周。在每周结束时的连续2天，他们将保存所有尿液24小时，并在早餐前将其带到MGH，在那里他们将收集早晨的血液。在随后的2周内，他们将每天3次随餐吞服碳酸氢钾（一种抗酸剂）、氯化钾（一种非抗酸剂）或安慰剂（一种惰性材料），并在每周结束时重复上述尿液和血液采集。参与者在第二个2周内接受的治疗将通过抽签决定，并对参与者和研究者保密，直到整个研究完成，以防止意外误导结果。通过测试所有的尿液和血液样本，我们可以看到是否中和他们多余的身体酸改善了参与者的骨代谢。如果是这样的话，未来更长时间的研究将测试抗酸剂是否可以防止艾滋病病毒感染患者中常见的骨质流失。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Volunteer patients with HIV infection and recent evidence of excess body acid will swallow an inert material (placebo) 3 times a day with meals for 2 weeks. On 2 consecutive days at the end of each week, they will save all their urine for 24 hours and bring it before breakfast to MGH, where they will have morning blood collected. For the subsequent 2 weeks, they will swallow either potassium bicarbonate (an antacid), potassium chloride (a non-antacid), or placebo (an inert material) 3 times a day with meals, and repeat the urine and blood collections as above at the end of each week. Which treatment a participant gets during this second 2 weeks will be decided by lottery, and kept secret from the participants and investigators until the entire study is completed, to prevent accidentally-misleading results. By testing all the urine and blood samples, we can see whether neutralizing their excess body acid improved the participants' bone metabolism. If so, future more prolonged studies will test whether antacids prevent the bone loss that is so common in HIV-infected patients.