SKIN SURFACE COOLING TO IMPROVE ORTHOSTATIC TOLERANCE AFTER PROLONGED BED REST

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。立位不耐受是在太空飞行后，在长时间卧床后，以及超过50万患有特发性立位不耐受的美国人中常见的现象。关于太空飞行，25%-66%的宇航员在着陆后2-3小时的站立测试中出现晕厥或晕厥症状。此外，许多宇航员在航天飞机重返大气层期间，当重力大于1.0Gz(即头到脚的矢量)10-15分钟，并达到1.8Gz的峰值时，会经历立位性低血压/耐受。由于宇航员面临明显的操作和安全问题，这种直立不耐受的高发生率引起了NASA的极大关注。因此，NASA高度重视寻找有效的对策，以减少与长期微重力暴露相关的立位不耐受的发生率。确定这样的对策也可能使患有特发性直立不耐受的人受益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Orthostatic intolerance is a common occurence following space flight, following prolonged bed rest, and in over 500,000 Americans who suffer from idiopathic orthostatic intolerance. With respect to space flight, 25-66% of all astronauts experience syncope or syncopal symptoms during a stand test 2-3 hours after landing. In addition, many astronauts experience orthostatic hypotension/intolerance during reentry of the space shuttle when gravitational forces are greater than 1.0 Gz (i.e. head to foot vector) for 10-15 min, and peak as high as 1.8 Gz. This high incidence of orthostatic intolerance is of substantial concern to NASA due to obvious operational and safety issues for the astronauts. Thus, NASA has placed a high priority on identifying an effective countermeasure to reduce the incidence of orthostatic intolerance associated with prolonged microgravity exposure. Identification of such a countermeasure may also benefit individuals with idiopathic orthostatic intolerance.