THE BOSTON MEDICAL CENTER BOSTON OBESITY, GENETICS AND LIFESTYLE (BOGL) STUDY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。我们建议成立波士顿医学中心波士顿肥胖遗传学和生活方式（BOGL）研究小组，以收集大量成年人的血浆样本，白色血细胞（DNA）和肥胖相关的健康信息。所有目前超重或肥胖，或减轻超重或肥胖的患者，包括目前或新的在波士顿医学中心营养和体重管理中心（NWMC）寻求治疗的患者，愿意参加这项观察性研究，都有资格参加。目标是招收1000名男性和1000名女性。将收集与心脏病、糖尿病和肥胖症的患者和家族史相关的信息。患者和医生可以决定任何减肥治疗方案。在基线后48周评估时，患者将接受随访电话访谈，或者如果在第48周时在诊所就诊，则接受面对面评估，以获取当前健康状况和过去48周的病史。此外，我们将审查与指定的48周期间有关的医疗记录，以确定测量的体重，验证健康信息，并确定此期间的治疗方案。受试者将继续在NWMC接受标准治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose the formation of the Boston Medical Center Boston Obesity Genetics and Lifestyle (BOGL) Study team in order to collect plasma samples, white blood cells (DNA) and obesity-related health information from a large population of adults. All presently overweight or obese, or reduced overweight or obese patients, including current or new patients seeking treatment at the Boston Medical Center Nutrition and Weight Management Center (NWMC) who are willing to participate in this observational study, are eligible. The goal is to enroll 1000 men and 1000 women. Information pertaining to patient and family history of heart disease, diabetes, and obesity will be collected. Patients and physicians may decide on any weight loss treatment options. At 48 weeks post-baseline assessment patients will receive follow-up phone interviews or, if seen in clinic at week 48, an in-person assessment, to capture current health status and history over the previous 48 weeks. In addition, we will review medical records pertaining to the specified 48 week period to ascertain measured body weight, verify health informaiton, and to determine the treatment protocols during this period. Subjects will continue to receive standard of care treatment as usual in the NWMC.