TESTOSTERONE DOSE RESPONSE IN SURGICALLY MENOPAUSAL WOMEN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。正常情况下，女性即使在绝经后，也会在卵巢中产生睾丸素。通过手术摘除双侧卵巢的女性通常睾丸激素水平较低，这可能导致性功能、肌肉功能和总体幸福感下降。这项研究的目的是确定对于绝经前摘除卵巢且血液中睾酮水平较低的女性，最合适的睾丸素剂量是多少。最合适的睾丸素剂量是使有益效果最大化而副作用最小化的睾丸素量。为此，我们将通过随机分配140名年龄在21岁到60岁之间的卵巢摘除女性，分成四组，每组接受安慰剂或三种剂量的睾丸素之一的每周注射，为期6个月(双盲)。在研究期间，受试者还将接受雌激素贴片治疗。睾丸激素的作用将通过测量瘦身组织、肌肉大小、肌肉力量和腿力、性功能和大脑功能来确定。我们还将测量血浆脂蛋白(血液中的胆固醇和一些胰岛素敏感性功能(身体如何处理糖)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normally women produce testosterone in their ovaries even after menopause. Women who have had both ovaries removed by surgery usually have low testosterone levels which may contribute to reduced sexual function, muscle function and general sense of well being. The purpose of this study is to determine what the most appropriate dose of testosterone is to give to women who have had their ovaries removed before menopause and have low testosterone levels in their blood. The most appropriate dose of testosterone will be the amount of testosterone that maximizes the beneficial effects while minimizing side effects. We will do this by randomly assigning 140 women between the ages of 21 and 60 who have had their ovaries removed to four groups which receive either placebo or one of three doses of testosterone by weekly injections for 6 months (double blind.) Subjects will also be treated with an estrogen patch during the study. The effects of testosterone will be determined by measuring lean body tissue, muscle size, muscle strength and leg power, sexual function and brain function. We will also measure plasma lippids (cholesterol in the blood and some functions of insulin sensitivity (how the body handles sugar).