LONG TERM EFFECTS OF SUBCLINICAL CAD ON CARDIAC FUNCTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。南湾心脏观察（SBHW）研究已经建立了一个明确的，但不完美的关系之间的钙在心脏（冠状动脉钙）和心脏疾病的无症状的成年人的风险。我们已经确定，这种关系在糖尿病受试者中降低，并且在冠状动脉钙的存在和量方面存在明确的种族特异性差异，特别是在非裔美国人和其他种族群体之间。我们提供的证据表明，冠状动脉钙作为动脉硬化的标志物，在预测心脏病方面独立于炎症标志物（如高敏C反应蛋白）。 本延续研究的目的是在现在的老年SBHW队列中检查基线钙水平和7年钙水平变化对心脏功能的影响。本研究还将研究这些老年受试者冠状动脉钙变化与未来心脏病之间的关系。我们将通过对775名南湾心脏观察幸存者进行心脏磁共振成像（MRI）来测量收缩和舒张功能来实现这些目标。这些测量用于确定心脏是否正常工作。这项拟议的研究还将研究冠状动脉钙评分变化之间的关系，包括那些没有MRI扫描的患者。 本研究将在两个不同的研究中心分两部分进行。第一部分将在Harbor-UCLA综合临床研究中心（GCRC）进行，第二部分将在洛杉矶县+南加州大学（LAC+USC）成像科学中心进行。在GCRC，将测量血压、心率、身高和体重。 将抽取血液进行分析，并进行ECG检查。MRI将在成像科学中心的第二部分进行。所有不可接受的植入物、器械和假体的清单将用于确定在计划进行MRI之前，这些东西不存在于受试者体内。所有MRI结果和任何偶然的关键结果（包括但不限于瓣膜异常、心功能不全、动脉瘤和血栓形成）将转发至统计咨询和研究中心（SCRC）。SCRC将向参与者发送所有报告。 受试者的风险极低，主要是疼痛和抽血时的瘀伤以及MRI期间可能的幽闭恐怖反应。幽闭恐惧症是我们为该手术建立的排除标准之一。另一方面，受试者将通过与我们的工作人员互动，更好地了解自己的健康状况。他们亦会被告知血压和脂蛋白水平，并得到适当的建议。因此，风险：收益比倾向于收益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The South Bay Heart Watch (SBHW) study has established the presence of a definite though imperfect relationship between calcium in the heart (coronary calcium) and heart disease in asymptomatic adults at risk. We have established that this relationship is reduced in diabetic subjects and that there are definite ethnic- specific differences in the presence and amount of coronary calcium, notably between African Americans and other ethnic groups. We have provided evidence that coronary calcium, as a marker for hardening of the arteries, acts independently from markers of inflammation like high sensitivity C reactive protein in predicting heart disease. The objective of this continuation is to examine the effect of baseline calcium and seven-year change in calcium extent on the function of the heart in the now elderly SBHW cohort. This study will also examine the relation between changes in coronary calcium and future heart disease in these elderly subjects. We will accomplish these goals by performing cardiac magnetic resonance imaging (MRI) on 775 South Bay Heart Watch survivors to measure systolic and diastolic function. These measurements are used to determine if the heart is working properly. This proposed research will also examine the relation between changes in coronary calcium scores, including those without MRI scans. The study will be done in two parts, at two different sites. The first part will take place at Harbor-UCLA General Clinical Research Center (GCRC) and the second part at Los Angeles County + University of Southern California (LAC+USC) Imaging Science Center. At the GCRC, blood pressure, heart rate, height and weight will be measured. Blood will be drawn for analysis and an ECG will be done. The MRI will take place during the second part, at the Imaging Science Center. A checklist of all unacceptable implants, devices and prostheses will be used to ascertain that these things are not present in the participant's body before being scheduled for MRI. The All MRI results and any incidental critical findings including, but not limited to, valvular abnormalities, cardiac dysfunction, aneurysm and thrombosis will be forwarded to the Statistical Consultation and Research Center (SCRC). SCRC will send out all reports to the participants. Risk to the subjects is minimal, mainly pain and bruising with blood drawing and possible claustrophobic reaction during the MRI. Claustrophobia is one of the exclusion criteria we have established for this procedure. On the other hand, the subjects will gain greater awareness of their health from their interactions with our staff. They will also be informed of their blood pressures and lipoproteins levels and be given appropriate advice. Therefore the risk: benefit ratio is leaning toward benefit.