TWIN AND FAMILY STUDIES OF THE ACUTE EFFECTS OF ALCOHOL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们假设，对酒精的急性反应的遗传变异会影响一个人的饮酒习惯和酗酒风险。因此，我们预测一个人对酒精的初始反应和急性适应都与酗酒家族史(FHA)和最近饮酒史(RDH)相关。我们还假设，基因影响的表现可能会随着大脑接触酒精的浓度的不同而不同。我们提出了3个项目来验证我们的预测。每个项目都采用静脉注射(Iv)酒精夹闭方法，我们最近的研究表明，这种方法能够保持呼气酒精浓度(Brc)，从而使大脑暴露在酒精中，随着时间的推移，几乎保持恒定的预先确定的水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that genetic variations in acute responses to alcohol influence a person's drinking habits and risk for alcoholism. Hence, we predict that an individual's initial response and acute adaptation to alcohol are both correlated with familial history for alcoholism (FHA) and recent drinking history (RDH). We also posit that manifestation of genetic influences may vary as a function of the concentration of brain's exposure to alcohol. We propose 3 projects to test our predictions. Each project employs the intravenous (iv) alcohol clamping method, shown in our recent studies to be capable of maintaining breath alcohol concentration (BrAC), and hence the brain's exposure to alcohol, at nearly constant, predeterminal levels over time.