MECHANISMS OF EXERCISE INTOLERANCE AND EFFECTS OF TRAINING IN CHILDREN WITH HEAE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本项目将招募6 - 13岁的儿童，其中Fontan手术后单心室儿童40例，心脏移植后儿童40例，健康儿童40例作为对照。报名参加的儿童将在夏季随机参加为期6周的运动训练项目或计算机课程。受试者在运动训练前后对门诊GCRC进行全天访问。进行营养评估、DEXA扫描、大腿MRI、超声心动图、肺功能检查、循环测力仪运动测试。抽血检测儿茶酚胺和细胞因子。家长们将填写两份调查问卷。GCRC访问结束后，受试者将佩戴活动监测器2周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will recruit children 6 to 13 years of age, including 40 children with single ventricle after the Fontan operation, 40 children after heart transplant, and 40 healthy children as controls. Enrolled children will be randomized to a 6-week exercise training program or computer class in the summer. Subjects will have one full-day visit to the outpatient GCRC before and after the exercise training. Nutrition assessment, DEXA scan, MRI of thigh, echocardiogram, pulmonary function test and cycle ergometer exercise test will be performed. Blood will be drawn for catecholamine and cytokine assays. The parents will fill out two questionnaires. After GCRC visit, the subjects will wear an activity monitor for 2 weeks.