PRENATAL METHAMPHETAMINE EXPOSURE AND CHILD DEVELOPMENT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。尽管甲基苯丙胺在某些地区的使用率很高，但人们对产前接触甲基苯丙胺对儿童发育的潜在神经毒性影响知之甚少。已经建立了一个社区研究网络，以便在甲基苯丙胺使用普遍的四个地区（爱荷华州、俄克拉何马州、加利福尼亚州和夏威夷）对产前接触甲基苯丙胺和儿童结局进行纵向研究。这个NIDA资助的项目建议进行一项为期三年的纵向发展跟踪研究。儿童将在新生儿期以及1岁、2岁和3岁时接受评估。当包括其他药物使用在内的协变量得到控制时，我们将检验有关产前甲基苯丙胺暴露对儿童结局影响的假设。还将研究与心理社会风险因素介导产前甲基苯丙胺暴露对儿童结局影响的作用有关的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the fact that methamphetamine use is very high in some regions, little is known about the potential neurotoxic effects of prenatal methamphetamine exposure on the development of children. A Community Research Network has been established to conduct a longitudinal study of prenatal methamphetamine exposure and child outcome in four areas (Iowa, Oklahoma, California, and Hawaii) in which methamphetamine use is prevalent. This NIDA funded project proposes to conduct a three-year longitudinal developmental follow-up study. Children will be evaluated in the newborn period and at ages 1,2 and 3. We will test hypotheses related to the effects of prenatal methamphetamine exposure on child outcome when covariates including other drug use are controlled. Hypotheses related to the role of psychosocial risk factors mediating effects of prenatal methamphetamine exposure on child outcome will also be studied.