DEVELOPING A PARADIGM TO DETECT SENSITIVITY TO THE RATE OF CHANGE OF BRAC

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们的实验室专门开出大脑暴露在酒精中的时间进程。我们已经证明，人类大脑对酒精浓度和大脑开始接触酒精的时间(对酒精的急性适应)都有反应。这个项目开始了我们对大脑对酒精时间变化率的反应的研究。在这项初步的发育研究中，我们寻求多节段恒斜率处方的最佳组合，以用于最终的科学研究，并构建一系列可以非常频繁地测量大脑功能的依赖测量，因为在整个实验过程中，brc将迅速变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our lab specializes in prescribing the time course of brain exposure to alcohol. We have demonstrated that the human brain responds to both the concentration of alcohol and the time since exposure of the brain to alcohol began (acute adaptation to alcohol). This project begins our study of the brain's response to the rate of change with respect to time of alcohol. In this preliminary developmental study, we seek the optimum combination of multi-segment, constant slope prescriptions for the BrAC to be used in an eventual scientific study, and to construct a battery of dependent measures of brain function that can be measured very frequently, since BrAC will be changing rapidly throughout the experiment.