NEUROPSYCHOLOGICAL DYSFUNCTION AND NEUROIMAGING ABNROMALITIES IN SCD

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是确定患有镰状细胞病的成年人记忆和注意力问题的程度。没有经历过中风或其他脑损伤的成年人将被要求加入这项研究。这项研究还将评估这些事件或情况与异常MRI之间的联系。这些发现将与背景相似的健康人进行比较。对于一些参与者来说，测试将显示记忆和注意力问题的证据，这可能是由大多数镰状细胞疾病患者发生的贫血引起的。纠正贫血与一些记忆力和注意力更好的非镰状细胞患者有关。这项研究的第二部分将包括对完成神经心理测试和核磁共振成像的受试者进行为期六个月的贫血治疗，以评估转核融合对记忆和注意力的影响。本研究的第二阶段为随机对照临床试验。这项研究的治疗组的患者将每月接受六次输液，作为一种改善记忆的潜在治疗方法。非干预组患者不接受输液治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to determine the extent of memory and attention problems in adults with sickle cell disease. Adults who have not experienced a stroke or other brain damage will be asked to join the study. The study will also evaluate the link between these events or conditions and abnormal MRI. These findings will be compared to healthy people with similar backgrounds. For some participants, testing will show evidence of problems with memory and attention, potentially caused by the anemia that occurs among most patients with sickle cell disease. Correcting anemia has been linked in some non-sickle cell patients with better memory and attention. A second part of the study will involve treating anemia for six months in a subset of subjects who have completed the neuropsychological testing and MRI to assess the effect of trnasfusion on memory and attention. This second study phase phase is a randomized controlled clinical trial. Patients in the treatment arm of the study will receive six monthly transfusions as a potential treatment to improve memory. Patients in the non-intervention group will receive no transfusion therapy.