FIRHAD

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。尽管研究举措旨在减少和消除健康和疾病方面的种族/族裔差距，但仍然存在很大的差距。研究人员通常将这些差异归因于饮食、吸烟和糟糕的医疗保健。虽然这些因素肯定会导致健康结果和疾病方面的差异，但越来越多的文献表明，除了这些因素外，健康结果还取决于心理社会、心理神经免疫、个性、应对(积极和消极)、情感、人际关系、宗教和社会人口变量的动态相互作用。这项研究项目将在预测肾脏健康和疾病的有效性的背景下，检验疾病和健康结果的生物心理社会模型的有效性。为了实现这一目标，一系列神经心理、个性、心理生理和心理社会措施的表现将与免疫、内分泌、肾脏和血糖功能指数进行比较。这项研究的参与者将包括来自华盛顿特区大都市区的300名(150名男性和150名女性)年龄在18岁及以上的非裔美国人的社区样本。这项研究还旨在检查远程保健技术作为一种工具的效用，以改变导致肾功能受损的行为/生活方式，以及这种情况发展为肾脏疾病及其终末期的情况。这项干预研究将在本研究的第三和第四年设计和实施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite research initiatives aimed at reducing and eliminating racial/ethnic disparities in health and disease, large disparities continue to exist. Typically researchers have attributed these disparities to diet, smoking and poor health care. While these factors certainly contribute to reacila/ethnic disparities in health outcome and disease, there is a growing literature which shows that in addition to these factors health outcomes are also determined by the dynamic interplay of psychosocial, psychoneuroimmunological, personality, coping (positive and negative), affective, interpersonal, religious, and sociodemographic variables. This research project will examine the validity of a biopsychosocial model of disease and health outcomes in the context of its efficacy in predicting renal health and disease. To achieve this objective, performance on a battery of neuropsychological, personality, and psychophysiological and psychosocial measures will be compared to indices of immune, endocrine, renal and glucose functions. Participants in this study will include a community-based sample of 300 (150 male and 150 females) african americans aged 18 and above from the washington, dc, metropolitan area. This study is also designed to examine the utility of telehealth technology as a tool for modifying behaviros/lifestyles that contribute to impaired renal functions and the progression of this condition to renal disease and its end stage. This intervention study will be designed and implemented during year three and four of this study.