NBP

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。近来，与创伤后应激障碍（PTSD）相关的医学发病率引起了人们的极大兴趣。心血管反应是生理反应的一个突出特征，是疾病的核心特征，这增加了对心血管功能产生持久影响的可能性。关于PTsd是否与高血压和相关心血管疾病发病率的风险增加有关的研究是混合的。 这项研究的目的是探讨将PTSD与心血管调节联系起来的候选机制，特别是夜间血压调节的作用，沿着创伤暴露和夜间血压关系的假设修饰符，包括特质愤怒和暴露于prejuice和歧视的作用。在研究的后续阶段，我们还将评估肾上腺素能受体的遗传多态性的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There has been much recent interest in medical morbidity associated with posttramatic stress disorder(PTSD). Cardiovascular response being a prominent feature of the phyciological reactivity that is a core feature of the disorder raises the possibility of enduring effects on cardiovascular function. Studies are mixed as to whether PTsd is associated with an increased risk of hypertension and related cardiovascular morbidity. The proposed study aims investigate candidate mechanisms for linking PTSD to cardiovascular regulation and, in particular, the role of nocturnal blood pressure regulation along with hypothesized modifiers of the relationship of trauma exposure and nocturnal blood pressure including the role of trait anger and exposure to prejuice and discrimination. In a subsequent phase of the research we will also evalute relationships to genetic polymorphisms of adrenergic receptors.