INSECT STING ANAPHYLAXIS: DETERMINANT OF CLINICAL REACTIVITY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是确定对昆虫叮咬有过敏反应的个体，以及未来叮咬可能再次引起过敏反应的个体，但发生这种情况的几率估计在25%至70%之间。目前，还没有办法确定哪些病人会对随后的蜜蜂叮咬产生反应。目前还没有可用的检测方法可以告诉哪些患者会有反应，反应可能有多严重，或者谁应该接受治疗。本研究的目的是测试有过昆虫叮咬反应的人是否有再次发生过敏性叮咬反应的风险。为了实现这一目标，患者将被蜜蜂或黄夹克蜇伤，这样就可以开发出一种方法来预测哪些患者需要进行预防性治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to identify individuals who have had an allergic reaction to an insect sting(s) and in whom a future sting could cause an allergic reaction again, but the chance of this occurring is estimated to be between 25% and 70%. At the present time, there is no way of determining which patients will have a reaction to subsequent bee stings. No currently available test can tell which patients will have a reaction or how severe the reaction could be, or who should be treated. The purpose of this study is to test whether people who have had an insect sting reaction(s) are at risk for another allergic sting reaction. To accomplish this goal, patients will be stung by a honeybee or yellow jacket so that a method can be developed for predicting which patients need to have preventive treatment.