LONG-TERM OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。自动神经心理评估指标（ANAM）是一种软件程序，利用在武装部队各个分支开发的测量和规范来创建对认知变化敏感的性能电池。一些研究已经证明ANAM能够捕捉与轻度创伤性脑损伤（MTBI）相关的细微认知变化。即使在那些在传统神经心理测试中没有下降的MTBI患者中，也观察到ANAM的表现下降。最近的研究结果表明，ANAM能够跟踪年轻成年男性运动相关脑震荡损伤后认知功能的恶化和恢复。ANAM已被用于评估成人SLE患者的认知障碍。ANAM的儿科适应性最近已经开发出来，并进行了初步验证研究。该电池是否对儿童NPSLE有用，将在本方案中进行研究。在这项研究中，患者自我报告的神经精神症状将与正式的神经认知测试结果进行比较。在成人中，通过正式的神经认知测试确定，较高的主观抱怨得分与较低的认知功能之间存在显著关联。在儿童期发病的系统性红斑狼疮中尚未进行类似的研究，这是本研究的重点。自我评估神经精神病学问卷（NSAQ）类似于上述研究中描述的用于成人的问卷，适用于儿童，并将用于确定认知的自我报告是否与当前标准的正式神经认知测试相媲美。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Automated Neuropsychological Assessment Metrics (ANAM) is a software program that utilizes measures and specifications developed in various branches of the Armed Forces to create a performance battery sensitive to cognitive change. Several studies have demonstrated the ability of the ANAM to capture subtle cognitive change associated with mild traumatic brain injury (MTBI). Performance decrements on the ANAM were observed even in those individuals with MTBI without decrement on traditional neuropsychological tests. Recent findings demonstrate the ANAM's ability to track deterioration and recovery of cognitive functioning following sports-related concussion injury in young adult males. The ANAM has been used for the assessment of cognitive impairment in adult SLE. The pediatric adaptation of the ANAM has been recently developed and initial validation studies have been performed. Whether this battery is useful for pediatric NPSLE will be studied in this protocol. In this study, patient self reports of neuropsychiatric symptoms will be compared with the results of formal neurocognitive testing. In adults, there is a significant association between higher subjective complaint scores and lower cognitive function as determined by formal neurocognitive testing. Similar studies have not yet been done in childhood onset systemic lupus erythematosus and are a focus of the presented research study. A Self Assessment Neuropsychiatric Questionnaire (NSAQ) similar to the one described in the studies above used in adults, was adapted for children and will be used to determine if self reports of cognition are comparable to the current standard of formal neurocognitive testing.