ADOLESCENT GASTRIC BYPASS AND DIABETIC PRECURSORS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目将开始一项关于胰岛素抵抗、β细胞功能、人体测量学、营养和身体活动的详细研究，将病态肥胖的成年人与接受减肥手术的青少年进行比较，研究与碳水化合物代谢的关系。虽然我们知道胃分流术可以减轻体重，从而纠正一些代谢问题，但我们不太清楚什么时候需要进行这些改变才能获得最佳的长期效果。有证据表明，如果长时间不治疗，胰腺可能会“烧坏”，然后新陈代谢问题可能不会完全逆转。将比较胃分流术对成人和青少年代谢的影响，以试图确定在生命早期进行胃分流术是否比等到成年后进行胃分流术更有利于代谢和健康。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will begin a detailed study of insulin resistance, beta cell function, anthropometrics, nutrition, and physical activity in morbidly obese adults compared to adolescents undergoing bariatric surgery in relation to carbohydrate metabolism. While it is known that gastric bypass causes the weight loss necessary to correct some metabolism problems, not much is known about when these changes need to happen to provide the best long term outcome. Evidence suggests that if left untreated for too long the pancreas can "burn out" and then the metabolism problems may be less completely reversed. The effects of gastric bypass on the metabolism of adults and adolescents will be compared to try to determine whether there are greater metabolic and health advantages of performing gastric bypass earlier in life versus waiting until adulthood.