ENDOCRINOPATHIES AFTER HEAD INJURY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。头部受伤导致内分泌疾病的儿童可能在受伤后几年内不会出现症状。目前尚无前瞻性试验报告评估儿童头部损伤后内分泌失调的发生率。 我们假设在损伤后6个月进行系统的内分泌评估，可以识别出那些有发展为后期内分泌病风险的儿童。具体而言，我们假设促甲状腺激素（TSH）或生长激素（GH）分泌的异常模式，或血清催乳素浓度升高，将预测其他下丘脑-垂体功能障碍的发展。 在当前的研究中，40名严重头部受伤的儿童将在受伤时和2至3个月后进行基线甲状腺、皮质醇、生长激素筛查和催乳素测量。然后，他们将在受伤后6个月接受他们夜间TSH和GH分泌模式的研究。随后，他们的生长速度和内分泌筛查测试将在受伤后一年进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children with endocrinopathies resulting from head injury may not present with symptoms for several years after the injury. No prospective trial has been reported assessing the frequency of endocrinopathy after head injury in children. We hypothesize that systematic endocrine evaluation six months after the injury will identify those children at risk for developing later endocrinopathy. Specifically, we hypothesize that an abnormal pattern of thyrotropin (TSH) or growth hormone (GH) secretion, or an elevated serum prolactin concentration, will predict development of other hypothalamic-pituitary dysfunctions. In the current study, 40 children who have survived significant head injury will have baseline thyroid, cortisol, growth hormone screen, and prolactin measurement at the time of injury and 2 to 3 months later. They will then undergo study of their pattern of overnight TSH and GH secretion at 6 months after injury. Subsequently, their growth rate and endocrine screening tests will be evaluated at one year after injury.