CARDIOVASCULAR DISEASE IN ADOLESCENTS WITH TYPE 2 DIABETES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。青少年中2型糖尿病的患病率急剧上升。这似乎是儿科人群肥胖患病率和严重程度增加的直接结果。在患有2型糖尿病的成年人中，患心血管疾病的风险相当高。目前尚不清楚患有2型糖尿病的青少年是否也有同样高水平的心血管疾病风险。如果他们这样做，那么预计他们将在20岁左右的S或30岁的S出现临床心血管疾病。这将具有重要的临床意义，并表明需要非常积极地管理心血管疾病危险因素和糖尿病。这项研究是对300名患有2型糖尿病的青少年人群的心脏和血管结构和功能的横断面评估，并与按年龄、性别和种族匹配的300名肥胖对照组和300名正常体重对照组进行比较。心血管疾病发展的评估将使用新的非侵入性成像方法，包括心脏结构和功能的超声心动图测量，颈动脉内膜-中层厚度、中央主动脉压力和增强指数的超声评估将使用SPhygomoCor脉搏波分析系统完成，以及通过臂动脉反应性评估内皮功能。这项研究的结果将填补一项重要的知识空白，将作为未来纵向研究的基线，并可能为预防年轻2型糖尿病患者心血管疾病的临床策略提供基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of type 2 diabetes mellitus has increased dramatically in adolescents. This appears to be a direct result of the increase in prevalence and severity of obesity in the pediatric population. In adults with type 2 diabetes, the risk for cardiovascular disease is quite high. It is not known if adolescents with type 2 diabetes have an equivalent high level of risk of CVD. If they do then it would be expected that they would develop clinical CVD in their late 20's or 30's. This would have important clinical implications and would suggest the need for very aggressive management of CVD risk factors and diabetes. This study is a cross-sectional evaluation of cardiac and vascular structure and function in a population of 300 adolescents with type 2 diabetes compared to an obese control group of 300 and a normal weight control group of 300 who have been matched by age, sex and race. Assessment of CVD development will be accomplished using novel non invasive imaging methods including echocardiographic measurement of cardiac structure and function, ultrasound evaluation of carotid intimal-medial thickness, central aortic pressure and augmentation index will be accomplished using the SphygomoCor Pulse Wave Analysis System and evaluation of endothelial function by brachial artery reactivity. The results of this study will fill an important gap in knowledge, will serve as the baseline for future longitudinal studies and may provide the basis for clinical strategies to prevent the development of CVD in young patients with type 2 diabetes.