AEROBIC PERFORMANCE, MOBILITY LIMITATIONS AND EXERCISE IN OLDER ADULTS WITH DIAB

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是在240名老年糖尿病患者中进行一项随机对照试验，以确定功能回路训练和活动定制干预/行为支持（带有家庭行为支持计划）或灵活性控制和健康教育计划（无行为支持）对峰值有氧能力、亚最大氧动力学、功能活动表现和自我报告功能的影响。男女都将被招募。我们将特别鼓励非裔美国人参与我们的招募，目标是达到与老年糖尿病患者相似的分布。其他少数族裔将根据他们在华盛顿县和西韦恩县（主要招聘地区）的百分比（3%亚裔美国人，2%西班牙裔美国人）招募。不涉及弱势群体（如精神错乱）。我们建议测试有氧运动表现与运动能力限制有关的假设，并且改善有氧运动表现的干预也会改善运动能力。鉴于许多老年糖尿病患者的身体活动水平较低，我们将专门测试提高亚最大有氧运动表现的运动干预是否也能改善活动能力。收集的大部分数据将直接来自人类受试者，形式包括问卷回答、实际观察到的表现、血液测试、DEXA扫描和超声心动图。我们还将要求通过检查其医疗记录来证实受试者访谈，其中可能包括与糖尿病有关的医生就诊次数和住院次数的信息。所有HIPAA要求都将被严格遵守。将尽最大可能保密。长期存在的协议已经到位，包括按主题编号进行数据编码，锁在文件柜中，并通过另一个位置的名称-数字密钥进行交叉引用。将采用全面的书面同意程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to conduct a randomized controlled trial in 240 older adults with diabetes to determine the effects of functional circuit training and activity tailored intervention/behavioral support (with a home program of behavioral support) or flexibility controls and a program of health education and no behavioral support) on measures of peak aerobic capacity, submaximal oxygen kinetics, functional mobility performance and self-reported function. Both sexes will be recruited. We will particularly encourage African Americans in our recruitment, with a goal of attaining a distribution similar to that of older diabetics. Other minorities will be recruited based on their percentage in Washtenaw county and western Wayne county, the primary recruitment region (3% Asian American, and 2% Hispanic). No vulnerable (such as demented) populations will be involved. We propose to test the hypothesis that aerobic performance is associated with mobility limitations, and that an intervention to improve aerobic performance will also improve mobility. Given the low physical activity levels of many older adults with diabetes we will specifically test whether exercise interventions that improve submaximal aerobic performance also improve mobility. The majority of data collected will be directly from the human subject, in the form of questionnaire responses, actual observed performance, blood tests, DEXA scan and echocardiogram. We will also request to corroborate the subject interview with inspection of their medical records which can include information about their number of physician visits and hospitalizations related to diabetes. All HIPAA requirements will be carefully followed. Confidentiality will be maintained to the fullest extent possible. Longstanding protocols have been in place, including data coding by subject number, locked in file cabinets, and cross-referenced by a name-number key in another location. A comprehensive written consent process will be employed.