SHORT-TERM EXERCISE, ?-CELL FUNCTION, AND INSULIN RESISTANCE IN OLDER PEOPLE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。血糖随着年龄的增长而升高，老年人患2型糖尿病(或成人糖尿病)的风险很高。在60岁以上的人中，饮用糖溶液后血糖升高(或糖耐量受损)也很常见。糖耐量受损的人患2型糖尿病的风险更高。胰岛素是人体产生的一种帮助控制血糖的荷尔蒙。糖耐量受损和糖尿病的人可能不会产生足够的胰岛素，也可能不会使用所产生的胰岛素。已有研究表明，短期锻炼能改善S身体对胰岛素的利用。这项研究的目的是想看看短期运动是否能改善S的身体，使用胰岛素是否也能提高胰岛素的生成量。这项研究可能有助于我们理解为什么老年人患糖尿病的风险增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Blood sugars increase with age, and older people are at high risk to develop type 2 diabetes (or adult onset diabetes). Increased blood sugars after drinking a sugar solution (or impaired glucose tolerance) is also common in people over age 60. People with impaired glucose tolerance are at increased risk to develop type 2 diabetes. Insulin is a hormone the body makes to help control blood sugars. People with impaired glucose tolerance and diabetes may not make enough insulin and may not use the insulin that is made as well. Short-term exercise has been shown to improve the body s use of insulin. The purpose of this research study is to see if short-term exercise to improve the body s use of insulin also improves how much insulin is made. This study may help us understand why older people are at increased risk to develop diabetes.