PROXIMAL TUBULAR SODIUM REABSORPTION IN AFRICAN-AMERICANS AND WHITES: A TUBULOC

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。严重的肾脏疾病导致的肾衰竭在非裔美国人中比白人更常见。高血压和糖尿病是导致肾脏疾病的最重要原因，但它们本身并不能解释种族差异。我们提出，肾脏处理盐(钠)和水的方式不同会影响肾脏的过滤单元，并导致损害，最终导致肾衰竭。这一建议是基于我们最近的观察，即血压正常的非裔美国人在关键部位，即近端小管，比白人更快地回收钠。在这项建议中，我们将描述近端肾小管钠重吸收的调节和整体肾脏钠的处理。我们假设，与白人相比，非裔美国人在刺激钠重吸收的因素上会有可测量的增加，而在抑制重吸收的机制上会减少。这些研究的目的是为了更好地了解肾小管运输的差异如何导致肾衰竭，特别是在非裔美国人中。我们预计，拟议的研究将导致开发一种诊断测试，以确定肾功能衰竭的易感性和监测治疗反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Serious kidney disease resulting in kidney failure is much more common in African-Americans than Whites. High blood pressure and diabetes are the most important causes of kidney disease, but they alone do not explain the racial difference. We have proposed that differences in how kidneys handle salt (sodium) and water can affect the filtering units of the kidney and result in damage that ultimately causes kidney failure. This suggestion is based on our recent observation that African-Americans with normal blood pressure reclaim sodium at a critical site, known as the proximal tubule, more rapidly than Whites. In this proposal, we will characterize the regulation of proximal tubular sodium reabsorption and overall kidney sodium handling. We hypothesize that African-Americans will have measurable increases in factors that stimulate sodium reabsorption and decreases in mechanisms that inhibit reabsorption compared to Whites. The goal of these studies is to provide a better understanding of how tubular transport differences contribute to kidney failure, particularly in African-Americans. We anticipate that the proposed studies will lead to the development of a diagnostic test for identifying a predisposition to kidney failure and monitoring response to therapy.