PULSE WAVE VELOCITY IN CRIC

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项由美国国立卫生研究院赞助的多中心纵向观察性研究是慢性肾功能不全队列(CRIC)研究(IRB#2001-0779)的补充研究，旨在检查慢性肾脏疾病患者的血管僵硬。根据CRIC的人群，研究对象将是种族和种族多样化的，年龄在21-74岁之间，患有轻度到中度的慢性肾脏疾病。在通常的CRIC研究访问期间，将进行额外的非侵入性程序来测量主动脉脉搏波速度和中心增强指数。休息5分钟后测量血压，并在皮肤上放置三个心电导联。定位颈动脉(颈动脉)脉搏，测量从颈动脉脉搏到胸骨切迹(胸骨顶部)的距离。AtCor PVX设备通过在颈动脉脉搏附近的皮肤上使用仪器获得20秒的波形信息来测量脉搏波速度。随后，对右股(腹股沟动脉)脉搏进行定位，并测量从股骨到肚脐到胸骨切迹的距离。使用相同的设备，在股脉搏测量脉搏波的速度。通过定位右桡(腕)动脉脉搏并获取10秒的波形信息来测量中央增强指数。大约需要20分钟才能获得所有测量结果。受试者将在基线或第一年CRIC就诊时以及2009年前每隔一年测量一次主动脉脉搏波速度和中心增强指数。所有信息在没有个人身份的情况下，通过基于网络的密码保护和加密系统传输到宾夕法尼亚大学，然后传输到数据协调中心进行数据分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This multi-center NIH-sponsored longitudinal observational study is an additional study to the Chronic Renal Insufficiency Cohort (CRIC) study (IRB # 2001-0779) designed to examine vascular stiffness in patients with chronic kidney disease. Based on the CRIC population, subjects will be ethnically and racially diverse and between the ages of 21-74 with mild to moderate chronic kidney disease. During the usual CRIC study visit, additional non-invasive procedures will be done to measure aortic pulse wave velocity and central augmentation index. Blood pressure is measured after 5 minutes rest and three ECG leads are placed on the skin. Carotid (neck artery) pulse is localized and distance from carotid pulse to sternal notch (top of breast bone) is measured. The Atcor PVX device measures pulse wave velocity by obtaining 20 seconds of wave form information using an instrument over the skin near the carotid pulse. Subsequently, the right femoral (groin artery) pulse is localized and distance measured from femoral to navel to sternal notch. Using the same device, the pulse wave velocity is measured at the femoral pulse. The central augmentation index is measured by localizing the right radial (wrist) artery pulse and obtaining ten seconds of wave form information. Approximately 20 minutes are required to obtain all measurements. Subjects will have aortic pulse wave velocity and central augmentation index measured at baseline or year 1 CRIC visit and every other year until 2009. All information, without personal identification, is transferred to University of Pennsylvania on a web-based password-secured and encrypted system to the data coordinating center for data analysis.