YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。采用高效抗逆转录病毒疗法大大改善了艾滋病毒感染者的生活质量，并大大降低了发病率和死亡率。但是，HIV感染和HAART与一系列代谢和拟人化综合征（HIV代谢综合征; HIV+MS）相关，这些综合征危及HIV感染者的长期心血管疾病（CVD）风险特征。这些并发症的原因是多方面的。安全和有效的传统治疗方法（药物，改变抗艾滋病毒药物）很少被确定。瑜伽生活方式的古老实践已经重新普及，作为一种补充，非传统的治疗代谢，拟人化和心血管疾病。瑜伽通过练习姿势、肌肉收缩、控制呼吸和冥想，在饮食习惯、运动和休息、呼吸方式以及身心关系之间提供综合控制和和谐平衡。生理过程之间的整体平衡可以缓解疾病。我们建议客观地检查瑜伽生活方式干预的安全性和有效性，其中26名女性和26名男性感染艾滋病毒，接受HAART治疗，并经历代谢综合征，增加CVD风险。我们假设瑜伽生活方式干预将是安全的，并增强（补充）HIV+ MS标准治疗的益处。参与者将被随机分配继续标准治疗，或在标准治疗基础上增加监督瑜伽生活方式干预。瑜伽生活方式干预将由Living By Design Inc.雇用的训练有素、经验丰富的瑜伽教练教授和监督，圣路易斯的一个医疗保健计划，为艾滋病毒感染者（和其他慢性疾病）提供补充和替代康复疗法。在4个月治疗前和治疗结束时，将对口服葡萄糖耐量、胰岛素敏感性、血清脂质/脂蛋白水平、纤维蛋白溶解和炎症的血清标志物、脂肪组织分布、心血管功能和CVD风险进行标准化和客观的测量。瑜伽生活方式的做法还没有客观地测试在替代管理战略的慢性感染与终身影响心血管疾病和其他健康风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The introduction of highly active antiretroviral therapy (HAART) has dramatically improved quality of life, and substantially reduced morbidity and mortality rates for people living with HIV. But, HIV-infection and HAART have been associated with a cluster of metabolic and anthropomorphic syndromes (HIV-metabolic syndrome; HIV+MS) that jeopardize long-term cardiovascular disease (CVD) risk profiles for people living with HIV. The cause of these complications is multifactorial. Few safe and effective traditional treatments (drugs, changing anti-HIV medications) have been identified. The ancient practice of a Yoga lifestyle has been re-popularized as a complementary, non-traditional treatment for metabolic, anthropomorphic, and cardiovascular disorder. Yoga provides integrated control and harmonious balance among eating habits, exercise, and rest, breathing style, and the mind-body relationship through the practice of postures, muscle contraction, controlled breathing, and meditation. Holistic balance among physiologic processes provides relief from disease. We propose to objectively examine the safety and efficacy of a yoga lifestyle intervention in 26 women and 26 men infected with HIV, treated with HAART and experiencing metabolic syndromes that increase CVD risk. We hypothesize that a yoga lifestyle intervention will be safe and enhance (complement) the benefits of standard-of-care therapy for HIV+MS. Participants will be randomly assigned to continue standard-of-care therapy, or add a supervised yoga lifestyle intervention to standard-of-care therapy. Yoga lifestyle intervention will be taught and supervised by trained and experienced yoga instructors employed by Living By Design Inc., a St. Louis-based healthcare program that provides complementary and alternative rehabilitative therapies to people living with HIV (and other chronic disorders). Standardized and objective measurements of oral glucose tolerance, insulin sensitivity, serum lipid/lipoprotein levels, serum markers of fibrinolysis and inflammation, adipose tissue distribution, cardiovascular function adn CVD risk will be quantified before and at the end of 4-months of therapy. Yoga lifestyle practices have not been objectively tested in alternative management strategy for a chronic infection with lifelong implications for CVD and other health risks.