SECONDARY PREVENTION OF SMALL, SUBCORTICAL STROKE (SPS3)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是确定有效的治疗方法，以预防症状性皮质下小卒中患者的卒中复发和认知功能下降。假设联合抗血小板治疗相对于阿司匹林治疗沿着将减少25%的复发性卒中。与常规治疗相比，积极的降压治疗将使卒中复发率降低25%。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study is to define efficacious therapies for prevention of stroke recurrence and cognitive decline in patients with symptomatic small subcortical stroke. The hypothesis is that combined antiplatelet therapy will reduce recurrent stroke by 25% relative to aspirin therapy along. Aggressive blood pressure lowering will reduce recurrent stroke by 25% relative to usual management.