STRUCTURAL MRI IMAGING IN HUNTINGTON'S DISEASE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。之前的磁共振成像(MRI)研究表明，在亨廷顿病(HD)被诊断为HD之前，具有HD基因突变的人的特定区域会发生脑萎缩。随着疾病的发展，脑萎缩蔓延到其他区域，尽管脑萎缩的进展模式并不是很好地描述。我们目前正在领导一项对症状前HD患者大脑结构和认知的纵向多点研究，这将有助于我们描绘出人们被诊断为HD之前发生的大脑变化。通过使用爱荷华大学开发的复杂软件，我们将分析20名患有HD基因突变并已被诊断为HD的个体的MRI扫描结果。这将使我们能够更好地描述整个疾病过程中大脑萎缩的进展情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous research with magnetic resonance imaging (MRI) has indicated that brain atrophy occurs in specific regions prior to Huntington's disease (HD) diagnosis in individuals who have the HD gene mutation. As the disease progresses, brain atrophy spreads to other regions, though the advancing pattern of brain atrophy is not well-characterized. We are currently leading a longitudinal multi-site investigation of brain structure and cognition in presymptomatic HD which will help us to delineate brain changes that occur before people are diagnosed with HD. By using sophisticated software developed at the University of Iowa, we will anlayze MRI scans of 20 individuals who have the gene mutation for HD and who have been diagnosed with the disease. This will allow us to better characterize the progression of brain atrophy throughout the course of the disease.