ALTERNATIVE STRESS MANAGEMENT APPROACHES IN HIV DISEASE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。一项研究旨在寻找旨在减少艾滋病毒患者的感知压力和提高应对有效性的干预措施。越来越多的对艾滋病毒患者以及癌症等其他慢性和潜在致命疾病患者的研究表明，各种用于压力管理的生物行为策略不仅可以缓解心理痛苦和提高应对技能，而且还可以通过神经内分泌-免疫系统调节来增强免疫功能。因此，这种干预战略具有相当大的潜力，可以减少心理和身体症状的数量，从而改善艾滋病毒感染者的生活质量。虽然有令人信服的证据表明神经内分泌和行为相互作用，特别是与免疫系统的压力效应，但这些相互作用对健康结果的影响才刚刚开始研究。与艾滋病毒携带者相关的长期和/或严重的心理压力可能会进一步损害疾病进展过程中的免疫功能，从而增加发病率和死亡率的风险。本研究小组使用的三种压力管理干预措施是：积极生活(LIVE)、太极(Tchi)和精神成长小组(SPRT)。目的是确定这三种短期干预措施和强化策略是否会改善患者的整体状况。在使用策略后，将在10周后、6个月后和12个月后收集数据。将采集血液样本，患者将带来唾液样本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A study to find interventions that are designed to reduce perceived stress and increase coping effectiveness in patients with HIV disease. A growing body of research with persons having HIV disease, as well as those with other chronic and potentially fatal illnesses such as cancer, indicates that a variety of biobehavioral strategies for stress management cannot only mitigate psychological distress and improve coping skills, but can also enhance immune function through neuroendocrine-immune system modulation. Such intervention strategies thus have considerable potential for lessening the amount of psychological and physical symptoms, thereby improving the quality of life of persons with HIV disease. While there is compelling evidence for neuroendocrine and behavioral interactions, especially stress effects with the immune system, the influences of these interactions on health outcomes is only beginning to be examined. Chronic and/or severe psychological stress associated with living with HIV disease may further compromise immune functioning over the illness progression, thereby increasing risks for morbidity and mortality. The three stress management interventions used by this study group are "positive living" (LIVE), Tai Chi (TCHI), and spiritual growth groups (SPRT). The aim is to determine if these three short-term interventions along with booster strategies will improve overall conditions for the patients. After strategies are used, data will be collected at the ten week mark, six months later, and twelve months later. Blood samples will be taken and patients will bring in saliva samples.