INFLUENZA IMMUNITY: PROTECTIVE MECHANISMS AGAINST A PANDEMIC RESPIRATORY VIRUS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。一项针对幼儿肌肉注射灭活疫苗（IM）免疫反应的IV期、单中心、开放标签研究受试者将被随机分配进行第二次抽血：a)第一次注射后10天，或b)第二次注射后10天。在接种疫苗和记录流感症状的日记卡之后，将对一部分人进行每周鼻拭子随访，以便在当地流感季节分析流感病毒的大流行性呼吸道病毒（PCR）证据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A Phase IV, single-center, open-label study of the immune responses of young children to inactivated vaccine given intramuscularly (IM). Subjects will be randomized to having their second blood draw taken either: a) 10 days after the first injection, or b) 10 days after the second injection. A subset will be followed with weekly nasal swabs to be analyzed for Pandemic Respiratory Virus (PCR) evidence of influenza virus during the local influenza season following immunization and diary cards for flu symptoms.