BETA-BLOCKER EFFECT ON REMODELING AND GENE EXPRESSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将比较三种不同的β-受体阻滞剂对充血性心力衰竭患者心脏结构、激素和细胞反应的影响。患者将被随机选择服用三种药物中的一种。在基线、3个月和12个月时进行各种检查，如超声心动图、心脏插管和核试验。没有“糖丸”，也没有安慰剂，患者会知道他们在服用什么药物。这项研究持续18个月。病人将在GCRC停留一至两晚。此外，患者可能会参加一项子研究，通过测量心脏的心输出量和压力读数来观察心脏对某些静脉注射心脏药物的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study which will look at how three different beta-blockers compare in effecting change in the structural, hormonal and cellular response of the heart, in patients who have "dilated" congestive heart failure. Patients will be randomly chosen to take either one of three types of medication. Various tests, such as echocardiogram, heart catheterization and nuclear tests, will be taken at baseline, at 3 months, and at 12 months. There is no "sugar pill", or placebo and patients will know what medication they are taking. The study lasts 18 months. Patients will be kept in the GCRC for one to two nights. Also, patients may participate in a substudy, which will look at how the heart responds to certain intravenous heart medications by measuring the cardiac output and pressure readings of the heart.