EFFCTS OF SEX HORMNS ON RESTNG ENRGY EXPND& SYMPATHETIC NERVOUS SYSTM ACTVITY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们正在进行一项研究，以确定生殖激素(雌激素和黄体酮)的影响。生殖激素水平随着年龄的增长而下降。静息时燃烧的卡路里(静息能量消耗)也会随着年龄的增长而减少，这可能会增加体重。这项研究的目的是弄清性激素的减少是否会导致能量消耗的减少。在这项研究中，我们将把绝经前妇女的正常生殖激素水平降低到与使用西曲肽的绝经后妇女相似的水平。然后，我们将测量静息能量消耗，以确定低雌激素和黄体酮水平是否会影响休息时燃烧的卡路里数量。还将对神经系统活动进行测量，以确定生殖激素如何调节能量消耗的变化。最后，我们将在五天内更换受试者的雌激素或黄体酮，然后重新测量静息能量消耗和神经系统活动，以确定每种激素对身体燃烧卡路里能力的单独影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are conducting a research study to determine the effects of reproductive hormones (estrogen and progesterone). Reproductive hormone levels go down with age. The number of calories burned at rest (resting energy expenditure) also decreases with age and this may weight gain. The purpose of this study is to find out whether the decrease in sex hormones causes the decrease in energy expenditure. In this study we will lower normal levels of reproductive hormones in premenopausal women to levels similar to those of postmenopausal women using the drug Cetrotide. We will then measure resting energy expenditure to determine whether low estrogen and progesterone levels affect the number of calories burned at rest. Measurements of nervous system activity will also be made to determine how reproductive hormones might mediate changes in energy expenditure. Finally, we will replace either estrogen or progesterone in subjects for five days and then re-measure resting energy expenditure and nervous system activity to determine the individual effects of each hormone on the body's ability to burn calories.