BALTIMORE HEALTH AND MENTAL HEALTH STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。骨质疏松症是一个重要的公共健康问题，随着国家人口的老龄化，它的重要性将越来越大。骨质疏松症与跌倒、骨折、残疾、行动不便和死亡的风险增加有关。最近的研究表明，抑郁史与骨密度（BMD）降低有关，即使在调整了其他协变量（如年龄和体重指数（BMI））后也是如此。迄今为止，大多数检验这种纵向关系的研究都受到抑郁症回顾性评估的限制。NIMH流行病学集水区（ECA）研究的巴尔的摩站点提供了基于人口概率样本的20多年前瞻性收集的精神病学和病史的详细特征，并提供了一个难得的机会来检查抑郁症和骨密度之间的关系。访谈分别于1981年、1982年、1993-6年及2004/5年进行。这是巴尔的摩ECA研究中的一项补充巢式病例对照研究，该研究与约翰霍普金斯大学精神病学助理教授Hochang Lee博士最近获得的K奖相协调。Lee博士的奖项是研究早期和中期抑郁综合征（重度抑郁症（MDD），轻度抑郁症和心境恶劣）与晚年认知能力下降之间的关系，使用选定的受试者子样本：125名60岁及以上有抑郁综合征史的ECA受试者和125名年龄，性别和教育程度相匹配的对照ECA受试者。这250名受访者被邀请在约翰霍普金斯医疗中心进行广泛的神经心理测试。这些受访者还被要求同意在访问约翰霍普金斯大学期间进行DEXA扫描。该方法利用GCRC的双能x射线吸收仪（DEXA）设备来评估骨密度。结果将为抑郁症作为骨质疏松症的危险因素提供新的可信数据，并提出可能解释这种关系的合理生物学途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoporosis is an important public health problem that will grow in significance as the nation's population ages. Osteoporosis is associated with increased risk of falls, fractures, disability, immobility and death. Recent studies have reported that history of depression is associated with reduced bone mineral density (BMD) even after adjustment for other covariates such as age and body mass index (BMI). To date, most of the studies that have examined this longitudinal relationship have been limited by retrospective assessments of depression. The Baltimore site of the NIMH Epidemiologic Catchment Area (ECA) Study provides a detailed characterization of over two decades of prospectively collected psychiatric and medical history on a population based probability sample, and is presented with a rare opportunity to examine the relationship between depression and BMD. Interviews have been conducted in 1981, 1982, 1993-6 and 2004/5. This is a supplemental nested case-control study within the Baltimore ECA Study, which is being coordinated with the recent K award of Dr. Hochang Lee, an assistant professor in the Department of Psychiatry at Johns Hopkins. Dr. Lee's award is to study the relationship between early and mid-life depression syndromes (Major Depressive Disorder (MDD), Mild Depression, and Dysthymia) and late life cognitive decline using a selected sub-sample of subjects: 125 ECA subjects aged 60 and older with a history of depressive syndrome and 125 age, sex, and education-matched control ECA subjects. These 250 respondents are invited for extensive neuropsychological testing at the Johns Hopkins medical complex. These respondents are also asked to agree to DEXA scans during their visit to Johns Hopkins. This utilizes the dual-energy x-ray absorptiometry (DEXA) facilities at the GCRC for assessment of BMD. Results will provide new credible data on depression as a risk factor for osteoporosis, and suggest plausible biological pathways that might explain the relationship.