PREVALENCE OF GROWTH HORMONE DEFICIENCY & RANGES OF IGF-1 IN NORMAL ELDERLY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。生长激素由脑垂体分泌，在婴儿期、儿童期和青春期引起身体生长。IGF-1是一种由肝脏响应GH分泌的蛋白质。IGF-1介导GH的大部分作用，因此大多数医生使用IGF-1作为GH缺乏的标志物。这是一项横断面临床研究，旨在确定50-90岁健康个体中胰岛素生长因子-1（IGF-1）的正常范围，并确定低IGF-1是否与低生长激素（GH）水平相关，并在其他健康老年个体中建立GH缺乏症的诊断。这个项目是与纽约大学老龄化和痴呆症中心合作完成的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Growth hormone is secreted by the pituitary gland and causes body growth during infancy, childhood, and adolescence. IGF-1 is a protein secreted by the liver in response to GH. IGF-1 mediates most of the actions of GH, so most physicians use IGF-1 as a marker for GH deficiency. This is a cross-sectional clinical study to determine the normal range for insulin growth factor-1 (IGF-1) in healthy individuals aged 50-90 and to determine whether low IGF-1 correlates with low growth hormone (GH) levels and establishes the diagnosis of GH deficiency in otherwise, healthy, elderly individuals. This project is being done in collaboration with the NYU Aging and Dementia Center.