THE EFFECT OF BEEF AND HEME IRON ON ZINC ABSORPTION IN CHILDREN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。铁和锌对儿童的健康至关重要。许多儿童缺乏铁或锌，这可能会产生长期后果。铁和锌缺乏症通常是由于摄入量低，加上生物利用度/吸收差。然而，许多因素可以改变铁和锌的吸收。事实上，它们可能会干扰彼此的吸收，因此增加饮食中的铁可能会减少锌的吸收，增加锌的摄入量可能会干扰铁的吸收。已知这种作用发生在非血红素铁（如补充剂）中，但不太清楚血红素铁（在肉类中发现）是否具有类似的作用。目前尚不清楚血红素铁是否会干扰儿童对锌的吸收，或者锌是否会干扰血红素铁的吸收。膳食蛋白质的来源也可能影响铁和锌的吸收。例如，有证据表明，牛肉蛋白可以增加铁的吸收，而大豆蛋白可能会减少铁的吸收。目前还不清楚这种影响是否也发生在锌的吸收上，或者这种影响是否在儿童中看到，他们是铁和锌缺乏的高风险人群。本研究的目的是了解血红素铁和锌对彼此吸收的影响，以及牛肉和大豆蛋白对儿童铁和锌吸收的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Iron and zinc are vital for health in children. Many children are iron or zinc deficient and this can have long-term consequences. Iron and zinc deficiencies usually occur because of low intakes, combined with poor bioavailability/ absorption. However many factors can modify the absorption of iron and zinc. Indeed, they may interfere with each others absorption so that increasing iron in the diet may reduce zinc absorption and increasing zinc intake may interfere with iron absorption. This effect is known to occur for non-heme iron (as in supplements) but it is less clear whether heme iron (found in meat) has a similar effect. It is not known if heme iron interferes with zinc absorption in children, or whether zinc interferes with heme iron absorption. The source of dietary proteins may also affect iron and zinc absorption. For example, there is some evidence that beef proteins increase iron absorption from the rest of the diet whilst soy proteins may decrease iron absorption. It is unclear whether this effect also occurs on zinc absorption, or whether the effect is seen in children, who are at high risk of both iron and zinc deficiency. The objective of this study is to understand the effect of heme-iron and zinc on each others absorption, and the effect of beef and soy protein on iron and zinc absorption, in children.