WOMEN'S HEALTH IN CYSTIC FIBROSIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。来自明尼苏达大学CF中心患者的数据表明，女性的死亡率高于男性，这似乎在青春期附近增加。假设是雌激素和孕激素可能对CF肺病有负面影响。本研究将检查正常排卵的年轻女性CF在月经周期的卵泡期和黄体期的肺功能。服用避孕药的CF女性的肺功能将与未服用避孕药的女性进行比较。还将获得关于绝经对肺功能、骨骼健康、血脂水平和心血管疾病影响的初步信息。如果有证据表明激素对肺功能有影响，可能会对未来的治疗产生影响，并有可能提高CF女性的生存率。GCRC提供了一个理想的位置，以便在整个研究期间抽血、痰液采集和其他数据采集期间与患者进行互动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data from patients seen at the University of Minnesota CF Center demonstrate greater mortality in women compared to men which appears to increase near the time of puberty. The hypothesis is that estrogen and progesterone may have a negative impact on CF lung disease. The present study will examine lung function during the follicular and luteal phases of the menstrual cycle in normally menstruating young women with CF. Lung function of women with CF on birth control pills will be compared to those that are not. Pilot information on the effect of menopause on lung function, bone health, lipid levels and cardiovascular disease will also be obtained. If there is evidence of hormonal influence on pulmonary function, there may be future therapeutic implications and the potential to improve survival in women with CF. The GCRC provides an ideal location to interact with patients during blood draws, sputum collection and other data collection throughout the studies.