CLINICAL IMPLICATIONS OF GASTRIC BYPASS SURGERY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。Roux-en-Y胃分流术是最常见的肥胖手术类型。它既会导致严重的胃容量限制，也会导致吸收不良。它与更大的体重减轻相关，但也比限制性手术(如胃束带)更容易出现并发症。可能的不良后果包括蛋白质缺乏、液体分布的异常变化以及瘦组织的过度丢失。目前尚不清楚为什么这种手术能在对一些人产生最小负面影响的情况下成功减肥，但对另一些人却不是。有必要确定与积极结果相关的因素，以便改善临床管理。这项拟议的研究将调查胃旁路手术后饮食摄入量、身体成分变化、静息能量代谢和营养状况之间的关系。其中一个主要假设是，术后前五到六周的蛋白质摄入量越大，术后6个月和1年的结果就越好。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Roux-en-Y gastric bypass is the most common type of obesity surgery. It induces both severe restriction of stomach capacity, and malabsorption. It is associated with greater weight loss, but also greater risk for complications than restrictive procedures (e.g. gastric banding). Possible adverse outcomes include protein deficiency, abnormal shifts in fluid distribution, and excessive loss of lean tissue. It is unclear why this surgery yields successful weight loss with minimal negative effects in some individuals, but not others. There is a need to identify factors associated with positive outcomes, in order to improve clinical management. The proposed study will investigate the relationships between dietary intake, changes in body composition, resting energy metabolism, and nutritional status after gastric bypass surgery. One of the primary hpotheses is that greater protein consumption in the first five to six weeks after surgery will be associated with more positive outcomes at 6 months and 1 year after surgery.