ABDOMINAL OBESITY AND RISK FACTORS FOR THE MET SYND AMONG HISPANIC AND NHW WOMEN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。以BMI为代表的肥胖与2型糖尿病（DM 2）和代谢综合征（MS）的风险增加相关，这些疾病在墨西哥裔美国人（MA）中的患病率很高。然而，脂肪的分布并不以BMI为特征，特别是在不同的种族群体中。例如，中国人在BMI较低时的脂肪水平与非西班牙裔白人（NHW）相同，而黑人在BMI较高时的脂肪水平相同。这种关系在MA中是未知的。同样未知的是腹部脂肪的关系，脂肪分布的测量，与给定水平的BMI或身体脂肪的MA。由于MA患DM 2的风险较高，因此MA在腹部或身体脂肪水平相同的情况下可能比NHW具有更高水平的MS风险因素。我们假设：1）MA和NHW女性在给定BMI水平下的腰围相似，但对于给定BMI，MA中腹部脂肪和全身脂肪的比例大于NHW; 2）MA中MS的风险因素水平高于NHW，但血压除外; 3）MA中血压低于NHW是由于植物性食物的摄入量更多。因此，我们建议研究身高，体重，腰围，全身脂肪，腹部脂肪的人体测量和双能X线吸收测定法，MS和DM 2的危险因素，饮食摄入量在200西班牙裔和NHW妇女。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity, as represented by BMI, is associated with increased risk of type 2 diabetes mellitus (DM2) and the metabolic syndrome (MS), conditions with a high prevalence in Mexican Americans (MA). However, the distribution of fat is not characterized by BMI, particularly in different ethnic groups. For example, Chinese have the same level of fat at lower BMI than non-Hispanic whites (NHW), whereas blacks have the same level of fat at higher BMI. This relation is unknown in MA. Also unknown is the relation of abdominal fat, a measure of fat distribution, with a given level of BMI or body fat in MAs. Because MAs are at higher risk of DM2, MA may have higher levels of risk factors for MS at the same level of abdominal or body fat than NHWs. We hypothesize 1) waist circumference is similar at the given level of BMI in MA and NHW women, but that the proportion of abdominal and total body fat is greater among MA than NHWs for a given BMI; 2) greater levels of risk factors for MS will occur at lower BMI in MAs than NHWs, except for blood pressure, and 3)lower blood pressure in MAs than NHWs is due to greater intake of plant foods. Therefore, we propose to study height, weight, waist circumference, total body fat, and abdominal fat by anthropometry and dual-energy x-ray absorptiometry, risk factors for MS and DM2, and dietary intake in 200 Hispanic and NHW women.