LOW DOSE INHALED NITRIC OXIDE FOR PREVENTION AND TREATMENT OF CHRONIC LUNG

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。一氧化氮是一种通常在肺部产生的天然气，它可以打开通往肺部的血管。呼吸少量一氧化氮气体对成人和患有其他类型疾病的婴儿的影响进行了研究，这些疾病会影响流向肺部的血液。到目前为止所做的测试表明，一氧化氮可以使血液更容易流向肺部，并可以改善流向肺部最健康部位的血液。一氧化氮已经用于少数使用呼吸机的患有严重CLD的早产儿。到目前为止，一些接受过一氧化氮治疗的CLD婴儿已经证明他们所需的氧气量减少了，随着时间的推移，他们已经能够耐受较低的呼吸机设置。重要的是要了解，高呼吸机压力和高氧气被认为是导致肺损伤的原因。这项研究的目的是确定如果早产儿在出生2周时仍需要使用呼吸机，如果他们通过呼吸机接受少量的一氧化氮，是否会降低患CLD的可能性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nitric oxide is a natural gas ordinarily produced in the lung, which opens the blood vessels going to the lungs. The effect of breathing small amounts of nitric oxide gas has been studied in adults and infants with other types of diseases affecting blood flow to the lungs. The tests done so far suggest that nitric oxide can make it easier for blood to flow to the lungs and can improve blood flow to the healthiest parts of the lung. Nitric oxide has been used in a small number of premature infants with severe CLD who are on ventilators. Some infants with CLD who have received nitric oxide so far have demonstrated a decrease in the amount of oxygen that they require, and over time they have been able to tolerate lower ventilator settings. It is important to understand that high ventilator pressures and high oxygen are known to contribute to lung injury. The purpose of this study is to determine whether premature babies who still need to be on the ventilator at 2 weeks of life will be less likely to develop CLD if they receive a small amount of nitric oxide through the ventilator.